Biotech

First Bionic Fingertip Implant Delivers Sensational Results (gizmag.com) 26

Posted by BeauHD from the sensational-textures dept.
Zothecula writes: Dennis Aabo Sorensen may be missing a hand, but he nonetheless recently felt rough and smooth textures using a fingertip on that arm. The fingertip was electronic, and was surgically hard-wired to nerves in his upper arm. He is reportedly the first person in the world to recognize texture using a bionic fingertip connected to electrodes that were surgically implanted above his stump. The device was created by scientists from the Ecole polytechnique federale de Lausanne in Switzerland, and Italy's Scuola Superiore Sant'Anna research institute. While it was wired to Sorensen, a machine moved it across rough and smooth plastic surfaces. Sensors in the fingertip generated electrical signals as they deformed in response to the topography of those surfaces, and transmitted those signals to the nerves in a series of electrical spikes -- this was reportedly an imitation of the "language of the nervous system." He was able to differentiate between the two surfaces with an accuracy of 96 percent.
Censorship

Draconian Aussie Science Censorship Law Takes Effect Next Month (theconversation.com) 265

Posted by timothy from the state-vs-man dept.
An anonymous reader writes: The Conversation reports that beginning next month Australian scientists and engineers face 10 years imprisonment for communicating without a government permit on biotech, robotics or manufacturing. Geoffrey Roberston QC says the laws are "sloppily drafted" and threatens research with "no sensible connection to military technology". But the government is barreling ahead, despite warnings from Defence Report it will kill Australia's high-tech economy. The law is opposed by Civil Liberties Australia where scientists are petitioning against it.
Australia

Pentagon Research Could Make 'Brain Modem' A Reality (thedailybeast.com) 86

Posted by BeauHD from the nanobots dept.
schwit1 writes: The Pentagon is attempting what was, until recently, an impossible technological feat -- developing a high-bandwidth neural interface that would allow people to beam data from their minds to external devices and back. That's right -- a brain modem. One that could allow a soldier to, for example, control a drone with his mind. On Feb. 8, the Defense Advanced Research Projects Agency (DARPA) -- the US military's fringe-science wing -- announced the first successful tests, on animal subjects, of a tiny sensor that travels through blood vessels, lodges in the brain and records neural activity. The so-called "stentrode," a combination stent and electrode, is the size of a paperclip and flexible. The tiny, injectable machine -- the invention of neurologist Tom Oxley and his team at the University of Melbourne in Australia -- could help researchers solve one of the most vexing problems with the brain modem: how to insert a transmitter into the brain without also drilling a hole in the user's head, a risky procedure under any circumstances.
Biotech

More Medical Devices Should Be Open Source, Like This ECG (github.com) 79

Posted by timothy from the zapping-you-with-kindness dept.
isza writes: This is a follow-up to the Slashdot story about mobilECG, a 12-lead, clinical-grade ECG being open sourced. We have not given up on our goal to get rid of the high-profit-margin and dishonest distribution practices of diagnostic ECGs, and make a certified open source version of this important diagnostic device. After many months of hard work, there is now a working prototype of a much more capable device than the first version, with its sources available on GitHub. MobilECG now has a Holter function, changeable lead-configurations and Bluetooth. Here's a video of the prototype working.
AI

Google DeepMind Applies AI To Healthcare With NHS Partnership (thestack.com) 33

Posted by yaelk from the robots-and-health dept.
An anonymous reader writes: Google's London-based AI group DeepMind has launched DeepMind Health, teaming up with the NHS to work on its first project. The "neuroscience-inspired" company, bought by Google in 2014, said of the collaboration: "We want to see the NHS thrive, and to ensure that its talented clinicians get the tools and support they need to continue providing world-class care." In its first initiative alongside kidney experts at London's Royal Free Hospital, DeepMind Health has introduced a mobile app called Streams. The software is designed to support the provision of critical information to doctors and nurses in order to help detect the presence of acute kidney injuries (AKI). To support the development of the Streams app, the AI group has also acquired clinical task management app company Hark.
Biotech

Researchers Claim Success In Removing HIV From Living Cells (nature.com) 107

Posted by timothy from the nobel-material dept.
ffkom writes: A recent publication from German researchers claims success in removing the HI-Virus from living cells, showing a way to completely cure AIDS rather than just suppressing its symptoms (by lowering the amount of viruses) by permanent medication: "Current combination antiretroviral therapies (cART) efficiently suppress HIV-1 reproduction in humans, but the virus persists as integrated proviral reservoirs in small numbers of cells. To generate an antiviral agent capable of eradicating the provirus from infected cells, we employed 145 cycles of substrate-linked directed evolution to evolve a recombinase (Brec1) that site-specifically recognizes a 34-bp sequence present in the long terminal repeats (LTRs) of the majority of the clinically relevant HIV-1 strains and subtypes. Brec1 efficiently, precisely and safely removes the integrated provirus from infected cells and is efficacious on clinical HIV-1 isolates in vitro and in vivo, including in mice humanized with patient-derived cells. Our data suggest that Brec1 has potential for clinical application as a curative HIV-1 therapy." Clinical trials are expected to start in Hamburg, Germany, soon.
Biotech

Fungi From Guts Of Herbivores Could Help Us Make Biofuel (dispatchtribunal.com) 44

Posted by BeauHD from the stubborn-plant-material dept.
hypnosec writes: Researchers have revealed through a new study that fungi from the gut of herbivores like goats, horses and sheep could be used to make biofuel. According to researchers at University of California, Santa Barbara, the fungi retrieved from these animals are capable of converting plant material into sugars that can be easily used to make biofuel and other products at the same efficiency as the best fungi engineering in the industry. Michelle O'Malley, lead author of the paper and professor of chemical engineering at the University, explains that these fungi naturally have the best possible set of enzymes for the job of breaking down biomass and as per their findings, these enzymes work together to break down stubborn plant material.
Biotech

3D-Printed Ear Comes To Life After Implantation In Mice (gizmag.com) 25

Posted by yaelk from the 3d-printing-news dept.
Zothecula writes: 3D printed tissues and organs have shown real potential in addressing shortages of available donor tissue for people in need of transplants, but having them take root and survive after implantation has proven difficult to achieve. In a positive move for the technology, researchers used a newly-developed 3D printer to produce human-scale muscle structures that matured into functional tissue after being implanted into animals.
Businesses

Startup Uses Sensor Networks To Debug Science Experiments (xconomy.com) 25

Posted by timothy from the watching-the-watchmen dept.
gthuang88 writes: Environmental factors like temperature, humidity, or lighting often derail life science experiments. Now Elemental Machines, a startup from the founders of Misfit Wearables, is trying to help scientists debug experiments using distributed sensors and machine-learning software to detect anomalies. The product is in beta testing with academic labs and biotech companies. The goal is to help speed up things like biology research and drug development. Wiring up experiments is part of a broader effort to create "smart labs" that automate some of the scientific process.
Biotech

DNA Makes Lifeless Materials Shapeshift (sciencemag.org) 26

Posted by yaelk from the shapeshifters dept.
sciencehabit writes: Researchers have engineered tiny gold particles that can assemble into a variety of crystalline structures simply by adding a bit of DNA to the solution that surrounds them. Down the road, such reprogrammable particles could be used to make materials that reshape themselves in response to light, or to create novel catalysts that reshape themselves as reactions proceed.
Biotech

Ethics Panel Endorses Mitochondrial Therapy, But Says Start With Male Embryos (sciencemag.org) 125

Posted by timothy from the keep-them-in-line dept.
sciencehabit writes: An experimental assisted reproduction technique that could allow some families to avoid having children with certain types of heritable disease should be allowed to go forward in the United States, provided it proceeds slowly and cautiously. That is the conclusion of a report released today from a panel organized by the U.S. National Academies of Sciences, Engineering, and Medicine (NAS), which assesses the ethics questions surrounding the controversial technique called mitochondrial DNA replacement therapy. More controversially, however, the panel recommended that only altered male embryos should be used to attempt a pregnancy, to limit the possible risks to future generations. (Males can't pass along the mitochondrial DNA that is altered in the procedure.)
Biotech

U.K. Researcher Receives Permission To Edit Genes In Human Embryos (sciencemag.org) 64

Posted by timothy from the just-blobs-of-tissue-after-all dept.
sciencehabit writes: Developmental biologist Kathy Niakan has received permission from U.K. authorities to modify human embryos using the CRISPR/Cas9 gene-editing technology. Niakan, who works at the Francis Crick Institute in London, applied for permission to use the technique in studies to better understand the role of key genes during the first few days of human embryo development.

The Human Fertilisation and Embryology Authority (HFEA), which grants licenses for work with human embryos, sperm, and eggs in the United Kingdom, approved Niakan's application at a meeting of HFEA's license committee on 14 January. The minutes of that meeting state that, '[o]n balance, the proposed use of CRISPR/Cas9 was considered by the Committee to offer better potential for success, and was a justified technical approach to obtaining research data about gene function from the embryos used.'
Biotech

Researchers Use CRISPR To Repair Genetic Defect That Causes Blindness (dispatchtribunal.com) 46

Posted by timothy from the ok-now-stop-lettuce-from-wilting dept.
hypnosec writes: In what has been claimed to be the first use of gene editing technique CRISPR for replacement of a defective gene associated with a sensory disease, researchers have repaired a genetic defect that causes blindness. The research that led to successful editing of defective genes responsible for retinitis pigmentosa (RP) – an inherited condition that causes the retina to degrade and leads to blindness in at least 1.5 million cases worldwide – was carried out using stem cells derived from a patient's tissue. Published in Scientific Reports, the study paves the way for using CRIPSR therapeutically to treat eye diseases.
Medicine

US Regulators Find Serious Deficiencies At Theranos Lab (wsj.com) 66

Posted by samzenpus from the worst-practices dept.
An anonymous reader writes: 2016 has not started well for blood-testing startup Theranos. Already facing allegations of data manipulation, the Centers for Medicare and Medicaid Services have found problems with Theranos' laboratory in Newark, California, putting the company's relationship with the Medicare program in danger. WSJ reports: "It isn't clear exactly what regulators have faulted Theranos for in their latest inspection, which took several months. Adverse findings would be another regulatory setback for one of Silicon Valley's highest-profile startups, valued at about $9 billion in 2014. Theranos already has stopped collecting tiny samples of blood from patients' fingers for all but one of its tests while it waits for the Food and Drug Administration to review the company's applications for wider use of the proprietary vials called 'nanotainers.' In October, the FDA said it had determined that the nanotainers were an 'uncleared medical device.'"
Biotech

Fraud Detected In Science Research That Suggested GMO Crops Were Harmful (nature.com) 357

Posted by samzenpus from the bad-numbers dept.
An anonymous reader writes: Three science papers that had suggested that genetically modified crops were harmful to animals and have been used by activist groups to argue for their ban have been found to contain manipulated and possibly falsified data. Nature reports: "Papers that describe harmful effects to animals fed genetically modified (GM) crops are under scrutiny for alleged data manipulation. The leaked findings of an ongoing investigation at the University of Naples in Italy suggest that images in the papers may have been intentionally altered. The leader of the lab that carried out the work there says that there is no substance to this claim. The papers' findings run counter to those of numerous safety tests carried out by food and drug agencies around the world, which indicate that there are no dangers associated with eating GM food. But the work has been widely cited on anti-GM websites — and results of the experiments that the papers describe were referenced in an Italian Senate hearing last July on whether the country should allow cultivation of safety-approved GM crops. 'The case is very important also because these papers have been used politically in the debate on GM crops,' says Italian senator Elena Cattaneo, a neuroscientist at the University of Milan whose concerns about the work triggered the investigation.
Biotech

Sensors Slip Into the Brain, Then Dissolve When Their Job Is Done (ieee.org) 20

Posted by samzenpus from the we-can-make-him-better dept.
An anonymous reader writes: Silicon-based electronic circuits that operate flawlessly in the body for some number of days--soon weeks--and then harmlessly dissolve: they're what University of Illinois professor John Rogers says is the next frontier of electronics. Today he released news of successful animal tests on such transient electronics designed for use in brain implants, but says they could be used just about anywhere in the body. As these devices move into larger animal and eventually human tests, Rogers says he'll be working on the next generation--devices that intervene to accelerate healing or manage medical conditions, not just monitor them.
Biotech

First Children Have Been Diagnosed In 100,000 Genomes Project (bbc.com) 75

Posted by timothy from the steps-into-the-future dept.
Zane C. writes: The 100,000 Genomes project, an organization dedicated to diagnosing and researching rare genetic disorders, has just diagnosed its first 2 patients. After painstakingly analyzing about 3 billion base pairs from the parents of one young girl, and the girl herself, "doctors told them the genetic abnormality — in a gene called KDM5b — had been identified". The new information will not yet change the way the young girl, named Georgia, is treated, but it opens up a path for future treatments. For the other girl, Jessica, the genetic analysis provided enough information to diagnose and begin a new treatment. A mutation had occurred "[causing] a condition called Glut1 deficiency syndrome in which the brain cannot get enough energy to function properly." Jessica's brain specifically had not been able to obtain enough sugar to power her brain cells, and as such, doctors prescribed a high fat diet to give her brain an alternate energy source. She has already begun showing improvement.
Biotech

New Class of Sound Wave Gentle Enough To Use In Biomedical Devices (dispatchtribunal.com) 14

Posted by timothy from the hello-in-there dept.
hypnosec writes: In a first kind of discovery in decades, researchers have created a new class of hybrid sound waves that are gentle enough to be used in biomedical devices. Known as "surface reflected bulk waves", the new class of sound waves are a hybrid of bulk waves and surface waves and have been created by a team at RMIT University in Melbourne, Australia. According to the team the new class of sound waves have already proved their worth in delivering vaccines and other drugs directly to the lung and are hopeful that their creation could lead to a revolution in stem cell therapy. As Dr Amgad Rezk, from RMIT's Micro/Nano Research Laboratory, explains, they have already dramatically improved the efficiency of an innovative new "nebuliser" that could deliver vaccines and other drugs directly to the lung in as little as 30 seconds [study abstract]. Researchers are hopeful that their work opens up the possibility of using stem cells more efficiently for treating lung disease enabling them to nebulise stem cells straight into a specific site within the lung to repair damaged tissue and this could be a real game changer for stem cell treatment in lungs as well as other organs.
Biotech

German Carpenter's Testicluar Valve Could Mean An On/Off Switch For Sperm 287

Posted by timothy from the this-one-goes-to-zero dept.
Press2ToContinue writes: A German carpenter has invented a valve which he claims will revolutionize contraception, by allowing a man to turn the flow of sperm from his testicles on and off at the flick of a switch. It (the switch, of course) is nearly an inch long and weighs less than a tenth of an ounce. It is surgically implanted on the vas deferens, the tube that carries sperm from the testicles, in a half-hour operation, and controlled by a switch beneath the skin of the scrotum.

So far Bimek is the only man who has the switches implanted, one for each testicle. I wonder what other switches we will see implanted into humans in the future? I think I'd like a valve for adrenaline control.
Biotech

DNA Manufacturing Enters the Age of Mass Production (ieee.org) 82

Posted by samzenpus from the making-life-better dept.
the_newsbeagle writes: Now that it's easy and cheap to build strands of DNA, what kinds of strange new organisms will scientists and start-ups build? That's the question raised as synthetic biology companies like Twist Bioscience and Zymergen start up their DNA manufacturing lines. Researchers who order DNA snippets typically pay on a cost-per-nucleobase basis. These companies say their mass-production techniques could bring prices down to 2 cents per base, which would allow researchers to scale up experiments and learn through trial and error.

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