An anonymous reader quotes a report from Ars Technica, written by Jennifer Ouellette: Over the holiday weekend, all but one member of the editorial board of Elsevier's Journal of Human Evolution (JHE) resigned "with heartfelt sadness and great regret," according to Retraction Watch, which helpfully provided an online PDF of the editors' full statement. It's the 20th mass resignation from a science journal since 2023 over various points of contention, per Retraction Watch, many in response to controversial changes in the business models used by the scientific publishing industry. "This has been an exceptionally painful decision for each of us," the board members wrote in their statement. "The editors who have stewarded the journal over the past 38 years have invested immense time and energy in making JHE the leading journal in paleoanthropological research and have remained loyal and committed to the journal and our authors long after their terms ended. The [associate editors] have been equally loyal and committed. We all care deeply about the journal, our discipline, and our academic community; however, we find we can no longer work with Elsevier in good conscience."

The editorial board cited several changes made over the last ten years that it believes are counter to the journal's longstanding editorial principles. These included eliminating support for a copy editor and a special issues editor, leaving it to the editorial board to handle those duties. When the board expressed the need for a copy editor, Elsevier's response, they said, was "to maintain that the editors should not be paying attention to language, grammar, readability, consistency, or accuracy of proper nomenclature or formatting." There is also a major restructuring of the editorial board underway that aims to reduce the number of associate editors by more than half, which "will result in fewer AEs handling far more papers, and on topics well outside their areas of expertise." Furthermore, there are plans to create a third-tier editorial board that functions largely in a figurehead capacity, after Elsevier "unilaterally took full control" of the board's structure in 2023 by requiring all associate editors to renew their contracts annually -- which the board believes undermines its editorial independence and integrity.

In-house production has been reduced or outsourced, and in 2023 Elsevier began using AI during production without informing the board, resulting in many style and formatting errors, as well as reversing versions of papers that had already been accepted and formatted by the editors. "This was highly embarrassing for the journal and resolution took six months and was achieved only through the persistent efforts of the editors," the editors wrote. "AI processing continues to be used and regularly reformats submitted manuscripts to change meaning and formatting and require extensive author and editor oversight during proof stage." In addition, the author page charges for JHE are significantly higher than even Elsevier's other for-profit journals, as well as broad-based open access journals like Scientific Reports. Not many of the journal's authors can afford those fees, "which runs counter to the journal's (and Elsevier's) pledge of equality and inclusivity," the editors wrote. The breaking point seems to have come in November, when Elsevier informed co-editors Mark Grabowski (Liverpool John Moores University) and Andrea Taylor (Touro University California College of Osteopathic Medicine) that it was ending the dual-editor model that has been in place since 1986. When Grabowki and Taylor protested, they were told the model could only remain if they took a 50 percent cut in their compensation.

An anonymous reader shared this report from the Wall Street Journal: The rich get richer — and older. People with high salaries and net worth tend to live longer lives, research shows. Once Americans make it to their late 50s, the wealthiest 10% live to a median age of around 86 years, roughly 14 years longer than the least wealthy 10%, according to a study published earlier this year in JAMA Internal Medicine. People with more money can afford healthier food, more healthcare and homes in safer, less-polluted neighborhoods, says Kathryn Himmelstein, a co-author of the study and a medical director at the Boston Public Health Commission.

Though you can't add more months or years to your online shopping cart yet, health and aging researchers say there are ways to spend money to improve your chances of living longer. They suggest favoring purchases that help you track your health, stay active and reduce stress. "We know the things that help us age better, and everyone's always disappointed when you tell them," says Andrew Scott, director of economics at the Ellison Institute of Technology in Oxford, England. "Eat less and eat better, sleep more, exercise more and spend time with friends...." But certain gadgets and luxuries can be worth the cost, some researchers say. Devices such as the Apple Watch and Oura Ring can instill healthy habits and catch worrying patterns that might emerge between annual checkups, says Joe Coughlin, the director of the MIT AgeLab... Coughlin says he once went to the emergency room because his Apple Watch detected a spike in his heart rate that he hadn't noticed himself.

"For the superwealthy, suddenly living longer and living better has become the new prestige," Coughlin says. Higher incomes correlate with longer lives, but there are diminishing returns. Each successive jump in pay is linked to smaller boosts in longevity, a 2016 study from the research group Opportunity Insights found... A key to the relationship between income and longevity is that money doesn't just buy stuff that helps you live longer. It also buys time and reduces stress. "If you've got a nice place to live and you don't have to worry about food on the table, you have the mental head space and resources to prioritize your health," says Steven Woolf, a professor at Virginia Commonwealth University School of Medicine... Moreover, many lower-income jobs are more physically taxing and more prone to workplace accidents and exposure to harmful substances.
The article also includes examples of spending that promotes health, including things like home gym equipment and even swing-dancing lessons.

But it also adds that "plenty of things that are good for you don't come with a bill, such as going on a walk or minimizing screen time before bedtime."

Research finds people who have more than four coffees a day have 17% lower chance of head and neck cancers. From a report: If the only thing getting you through a mountain of present-wrapping is a mug of tea or coffee, be of good cheer. Researchers have found people who consume those drinks have a slightly lower risk of head and neck cancers. There are about 12,800 new head and neck cancer cases and about 4,100 related deaths in the UK every year, according to Cancer Research UK.

The new study does not prove that tea and coffee are themselves protective against such cancers, but experts say the findings help to shed light on what has been a much debated area with inconsistent results. "While there has been prior research on coffee and tea consumption and reduced risk of cancer, this study highlighted their varying effects with different sub-sites of head and neck cancer including the observation that even decaffeinated coffee had some positive impact," said Dr Yuan-Chin Amy Lee of Huntsman Cancer Institute and the University of Utah School of Medicine, the senior author of the study.

Writing in the journal Cancer, the team report how they analysed data from 14 studies that covered Europe, North America and Latin America. [...] After taking into account factors such as age, sex, daily number of cigarettes smoked, alcohol consumption and fruit and vegetable consumption, the researchers found that people who drink more than four cups of caffeinated coffee a day have a 17% lower chance of developing head and neck cancers overall compared with those who do not drink the beverage. Specifically they found such consumption was associated with reduced odds of cancers of the oral cavity and the oropharynx -- part of the throat just behind the mouth.

An anonymous reader shared this report from Health magazine: "Most people think of aging as occurring gradually, constantly, and linearly," senior study author Michael Snyder, PhD, a professor of genetics and director of the Center for Genomics and Personalized Medicine at Stanford University, told Health. But "we're not just changing gradually over time; there are some really dramatic changes," Snyder said in a news release. "It turns out the mid-40s is a time of dramatic change, as is the early 60s. And that's true no matter what class of molecules you look at."

And these molecular changes aren't insignificant to our health — they were seen in molecules related to cardiovascular disease, skin and muscle health, immune regulation, and kidney function, among others... [R]esearchers from Stanford University and Nanyang Technological University in Singapore used data from 108 participants between the ages of 25 and 75. Those participants donated blood and other biological samples (stool samples, oral and nasal swabs) every few months over the course of several years. From those samples, researchers were able to track age-related changes in more than 135,000 different molecules and microbes in the participants' bodies.

The analysis showed that the majority of molecules and microbes underwent major changes in their abundance (increasing or decreasing) during two time periods: when people were in their mid-40s and early 60s... The molecules that showed extreme changes in a person's 40s, for example, were related to alcohol, caffeine, and lipid metabolism, as well as cardiovascular disease and skin and muscle health. Meanwhile, molecular changes in a person's 60s were related to carbohydrate and caffeine metabolism, immune regulation, kidney function, cardiovascular disease, and skin and muscle health. According to experts, these changes might show up as a reduced ability to metabolize caffeine and alcohol, suggesting that it may be wise to cut back on those substances. People in their 40s and 60s may also see a greater risk of developing cardiovascular disease, and people in their 60s may benefit from supporting their immune systems.
The article ends with this advice from Dr. Ronald DePinho, a cancer biology professor at the University of Texas's cancer center: there's ways to manage or slow some of the changes associated with aging.

"The easiest way to do that is through lifestyle changes, said DePinho — that means staying active, eating and sleeping well, managing stress, and avoiding smoking and excessive alcohol."

Scripps Research scientists sent stem-cell-derived brain organoids to the ISS to study the effects of microgravity on brain cells, finding that the organoids matured faster and showed signs of specialization compared to Earth-grown controls. The findings have been published in the journal Stem Cells Translational Medicine. Phys.Org reports: To examine how the space environment impacts cellular functions, the team compared the cells' RNA expression patterns -- a measure of gene activity -- to identical "ground control" organoids that had remained on Earth. Surprisingly, they found that the organoids grown in microgravity had higher levels of genes associated with maturity and lower levels of genes associated with proliferation compared to the ground controls, meaning that the cells exposed to microgravity developed faster and replicated less than those on Earth. "We discovered that in both types of organoids, the gene expression profile was characteristic of an older stage of development than the ones that were on the ground," [says co-senior author Jeanne Loring, Ph.D., professor emeritus in the Department of Molecular Medicine and founding director of the Center for Regenerative Medicine at Scripps Research]. "In microgravity, they developed faster, but it's really important to know these were not adult neurons, so this doesn't tell us anything about aging."

The team also noted that contrary to their hypothesis, there was less inflammation and lower expression of stress-related genes in organoids grown in microgravity, but more research is needed to determine why. Loring speculates that microgravity conditions may more closely mirror the conditions experienced by cells within the brain compared to organoids grown under conventional lab conditions and in the presence of gravity. "The characteristics of microgravity are probably also at work in people's brains, because there's no convection in microgravity -- in other words, things don't move," says Loring. "I think that in space, these organoids are more like the brain because they're not getting flushed with a whole bunch of culture medium or oxygen. They're very independent; they form something like a brainlet, a microcosm of the brain." "The next thing we plan to do is to study the part of the brain that's most affected by Alzheimer's disease," says Loring. "We also want to know whether there are differences in the way neurons connect with each other in space. With these kinds of studies, you can't rely on earlier work to predict what the result would be because there is no earlier work. We're on the ground floor, so to speak; in the sky, but on the ground floor."

The use of lead in gasoline "might have harmed the mental health of a generation," reports USA Today. Gen X bears an extra burden of conditions such as depression, anxiety, ADHD and neurotic behavior because of the leaded gasoline they were exposed to as children, according to a study published Wednesday in the peer-reviewed Journal of Child Psychology and Psychiatry. Leaded gas was banned in the United States in 1996, but the study said years of exposure during development made them particularly vulnerable.

Lead gas peaked from the mid-1960s through the mid-1970s, and children born during that era would later develop some of the highest rates of mental health symptoms, the study said. The study also linked leaded gas to "disadvantageous" traits, such as struggling to concentrate, stay on task or organizing thoughts. "I tend to think of Generation X as 'generation lead,'" said Aaron Reuben, a study co-author and assistant professor of clinical neuropsychology at the University of Virginia. "We know they were exposed to it more and we're estimating they have gone on to have higher rates of internalizing conditions like anxiety, depression and symptoms of attention deficit hyperactivity disorder...."

Researchers linked the lead exposure to an estimated 151 million "excess mental disorders" in the United States over the 75-year period. The estimates should be "considered a floor" because it relies mainly on gas and not exposure from lead in paint and pipes, Reuben said... Those born between 1966 and 1986 generally had higher mental illness levels linked to lead exposure with the rates peaking for those born between 1966 and 1970, the study said. Those rates coincided with the peak use of lead in gas from the mid-1960s through the mid-1970s... The study said the peak lead use coincided with increased demand for psychiatric care and higher rates of juvenile delinquency.
Today there's routine blood screenings for high levels of lead, study co-author Reuben says. But in the 1960s, 1970s, and 1980s, "folks were walking around with an average blood lead value that today would trigger clinical follow-up."

Wednesday Cuba's energy grid collapsed, "leaving millions without power," CNN reported, calling it "the latest in a series of failures on an island struggling from creaking infrastructure, natural disasters and economic turmoil."

Today Reuters reports: Cuba said it had reconnected its national electrical grid on Thursday, though generation remained well below demand one day after a plant failure knocked out power to millions across the island... Around half of Cuba's power generation facilities are offline for maintenance or broken down. All are decades old and producing well under capacity.

As a result, a majority of Cuba's residents suffer hours-long, rolling blackouts on a daily basis even when the grid is functional. Cuba's electrical grid has been on the brink of collapse for years, as fuel shortages, a string of natural disasters and an economic crisis have left the island's government unable to maintain the system's decrepit infrastructure. Dwindling oil imports from Venezuela, Russia and Mexico tipped the system into full crisis this year, leading to several nationwide blackouts that have sparked unrest and increasing anger among the population. The blackouts, together with food, medicine and water shortages, have vastly complicated life on the island and driven a record-breaking exodus of its residents since 2020.
Authorities informed Cuba's citizens that scheduled power outages will now resume, reports ABC News. "Cuban authorities said they will continue their current practice of implementing daily, five-hour power outages by block or zone as they have been doing for the past few months."

The Washington Post reports on tens of thousands of Americans "forced to pay for medication" to prevent the HIV infections, "despite federal requirements guaranteeing free access to treatment...according to multiple studies and interviews with medical professionals, activists and patients." Insurance companies are skirting rules compelling them to pay for pre-exposure prophylaxis treatment, known as PrEP, researchers and HIV advocacy organizations say — leaving patients to shell out hundreds of dollars each year for medication co-pays, doctor visits and screenings required to stay on drugs that reduce the risk of contracting HIV through sex by 99 percent.

Under the Affordable Care Act, commercial insurers must cover certain preventive health services. This is supposed to include at least one form of oral PrEP and related health services, such as regular testing for HIV and other sexually transmitted diseases, for people at increased risk of contracting HIV, according to 2021 guidance from the Biden administration. Responding to complaints that patients were still being charged, the Biden administration in October released new guidance instructing private insurers to cover all forms of PrEP without prior authorization, including new long-acting injections.

Nearly a third of a national sample of 325 health coverage plans on government insurance marketplaces did not include PrEP on their lists of covered preventive services, according to the AIDS Institute, a New York-based nonprofit. Between 20 and 30 percent of PrEP users with commercial insurance still had to pay for it despite the coverage mandate, with an average cost of $227 for 2022, according to the Centers for Disease Control and Prevention. Government regulators have been slow to crack down on insurer violations, activists say, creating a barrier to getting more at-risk Americans on the medication. The CDC estimates that only a third of the more than 1 million people who could benefit from PrEP have received a prescription, according to its most recent data.
The issue appears to be lax enforcement against insurers who break rules, a policy advocate told the newspaper. America's Centers for Medicare and Medicaid Services, which enforces regulations for preventive care, "said it takes enforcement seriously and recently found two insurance plans in violation of coverage requirements following consumer complaints."

And the Post spoke to an official at America's Labor Department, who said they were investigating a complaint against a large insurance company, but "said the agency does not have enough staff to conduct proactive investigations and lacks the authority to sue and penalize insurers that break the rules."

An anonymous reader shares a report: Nearly three-quarters of U.S. adults are overweight or obese, according to a sweeping new study. The findings have wide-reaching implications for the nation's health and medical costs as it faces a growing burden of weight-related diseases.

The study reveals the striking rise of obesity rates nationwide since 1990 -- when just over half of adults were overweight or obese -- and shows how more people are becoming overweight or obese at younger ages than in the past. Both conditions can raise the risk of diabetes, high blood pressure and heart disease, and shorten life expectancy.

The study's authors documented increases in the rates of overweight and obesity across ages. They were particularly alarmed by the steep rise among children, more than one in three of whom are now overweight or obese. Without aggressive intervention, they forecast, the number of overweight and obese people will continue to go up -- reaching nearly 260 million people in 2050. Further reading: Adipose tissue retains an epigenetic memory of obesity after weight loss.

NBC News reports that a newly identified chemical byproduct "may be present in drinking water in about a third of U.S. homes, a study found."

"Scientists do not yet know whether the byproduct is dangerous. But some are worried that it could have toxic properties because of similarities to other chemicals of concern." The newly identified substance, named "chloronitramide anion," is produced when water is treated with chloramine, a chemical formed by mixing chlorine and ammonia. Chloramine is often used to kill viruses and bacteria in municipal water treatment systems. Researchers said the existence of the byproduct was discovered about 40 years ago, but it was only identified now because analysis techniques have improved, which finally enabled scientists to determine the chemical's structure.

It could take years to figure out whether chloronitramide anion is dangerous — it's never been studied. The researchers reported their findings Thursday in the journal Science, in part to spur research to address safety concerns. The scientists said they have no hard evidence to suggest that the compound represents a danger, but that it bears similarities to other chemicals of concern. They think it deserves scrutiny because it's been detected so widely...

David Reckhow, a research professor in civil and environmental engineering at the University of Massachusetts, Amherst, who was not involved with the study, said the finding was an important step. The ultimate goal, he said, is understanding whether the substance is a hazard; he concurred that it was likely toxic. "It's a pretty small molecule and it can probably for that reason enter into biological systems and into cells. And it is still a reactive molecule," he said. "Those are the kinds of things you worry about."
"It's estimated more than 113 million people drink chloraminated processed water in the U.S.," according to a follow-up article by ABC News.

But they also include this quote from Dr. Stephanie Widmer, a board-certified medical toxicologist and emergency medicine physician. "The reality is that no one really knows too much about this chloronitramide and its impact on human health, and more research needs to be done. These disinfecting chemicals have been giving us clean drinking water for decades, so no reason to fear drinking water as a result of this study." Although ABC News tacks on this sentence.

"The study authors suggest, in general, adding a carbon filter to a sink or a standalone pitcher may be a good option for those concerned."

Thanks to long-time Slashdot reader Greymane for sharing the news.

Neuralink, the brain chip startup founded by Elon Musk, says it has received approval to launch its first clinical trial in Canada for a device designed to give paralysed individuals the ability to use digital devices simply by thinking. Reuters reports: [T]he Canadian study aims to assess the safety and initial functionality of its implant which enables people with quadriplegia, or paralysis of all four limbs, to control external devices with their thoughts. Canada's University Health Network hospital said in a separate statement that its Toronto facility had been selected to perform the complex neurosurgical procedure. Neuralink has successfully implanted the device in two patients in the United States. One of the patients has been using it to play video games and learn how to design 3D objects.

Dr. Adam Rodman, a Boston-based internal medicine expert, helped design a study testing 50 licensed physicians to see whether ChatGPT improved their diagnoses, reports the New York TImes. The results? "Doctors who were given ChatGPT-4 along with conventional resources did only slightly better than doctors who did not have access to the bot.

"And, to the researchers' surprise, ChatGPT alone outperformed the doctors." [ChatGPT-4] scored an average of 90 percent when diagnosing a medical condition from a case report and explaining its reasoning. Doctors randomly assigned to use the chatbot got an average score of 76 percent. Those randomly assigned not to use it had an average score of 74 percent.

The study showed more than just the chatbot's superior performance. It unveiled doctors' sometimes unwavering belief in a diagnosis they made, even when a chatbot potentially suggests a better one.

And the study illustrated that while doctors are being exposed to the tools of artificial intelligence for their work, few know how to exploit the abilities of chatbots. As a result, they failed to take advantage of A.I. systems' ability to solve complex diagnostic problems and offer explanations for their diagnoses. A.I. systems should be "doctor extenders," Dr. Rodman said, offering valuable second opinions on diagnoses.
"The results were similar across subgroups of different training levels and experience with the chatbot," the study concludes. "These results suggest that access alone to LLMs will not improve overall physician diagnostic reasoning in practice.

"These findings are particularly relevant now that many health systems offer Health Insurance Portability and Accountability Act-compliant chatbots that physicians can use in clinical settings, often with no to minimal training on how to use these tools."

Remember those 43 monkeys that escaped from a U.S. research lab? They've caught 35 of them — but haven't yet caught the other eight.

But even worse... The Independent reports that now another animal escape has led to "reports of two large emus running riot..." The birds' owner, Sam Morace, took to social media to plead with locals for their patience, saying: "For everyone that keeps seeing an emu, yes it is mine. There are 2 of them out." Morace said their two flightless birds broke loose three months ago.... "They are feral and not trained like the ones we have at the house."
This provoked some discussion on Facebook. ("Does nobody learn to lasso anymore?") But Morace responded that you "can't lasso a bird you have to grab them by their feet. Their necks are super long and fragile." In another post Morace detailed efforts to capture their birds. "Local law enforcement has already been at my house, we are trying to get a tranquilizer approved so we can bring them home.

"Thank you for all the concerns and questions. But if the emus were that easy to catch they would be home already.

If you're wondering how the escaped monkeys are doing out in the wild, someone who photographed them earlier this week said they appeared "playful, curious and jumping from tree to tree." The Guardian reports local officials have now "requested that the public avoid using drones near the facility. Earlier in the week, they reported that a drone incident 'spooked' the monkeys, increasing their stress levels and complicating efforts to recapture them."

Their article also notes reports that the facility houses 7,000 monkeys. And this isn't the first time some have escaped... In 2016, 19 monkeys escaped from the same facility, according to the Post and Courier newspaper, but were returned after six hours. Earlier, in 2014, 26 macaques reportedly escaped and were captured within two days. Documents from federal regulators from previous years revealed other incidents at the facility, as reported by the New York Times. One involved a primate escaping while being transported to the medical clinic and subsequently disappearing into the woods. Another involved two monkeys breaking out of their outdoor chain-link enclosure, which reportedly resulted in one monkey being lured back inside and the other dying shortly after being recaptured. In 2017, the Department of Agriculture fined the company more than $12,000 partly due to failures to contain the animals, according to the New York Times.
The Guardian also links to a related read from February: "Plan for US 'mini-city' of 30,000 monkeys for medical research faces backlash." Over the next 20 years, the facility will assemble a mega-troop of about 30,000 long-tailed macaques, a species native to south-east Asia, in vast barn-like structures in Bainbridge, Georgia, which has a human population of just 14,000... But the plan faces fierce opposition, with some Bainbridge residents calling on local authorities to block the construction of the proposed primate manse. "They're an invasive species and 30,000 of them, we'd just be overrun with monkeys," claimed Ted Lee, a local man. "I don't think anybody would want 30,000 monkeys next door," added David Barber, who would live just 400ft from the new facility.

A University of Zagreb virologist treated her own recurring breast cancer by injecting laboratory-grown viruses into her tumor, sparking debate about self-experimentation in medical research. Beata Halassy discovered her stage 3 breast cancer in 2020 at age 49, recurring at the site of a previous mastectomy. Rather than undergo another round of chemotherapy, she developed an experimental treatment using oncolytic virotherapy (OVT).

Over two months, Halassy administered measles and vesicular stomatitis viruses directly into the tumor. The treatment caused the tumor to shrink and detach from surrounding tissue before surgical removal. Post-surgery analysis showed immune cell infiltration, suggesting the viruses had triggered an immune response against the cancer. Halassy has been cancer-free for four years. OVT remains unapproved for breast cancer treatment worldwide. Nature adds: Halassy felt a responsibility to publish her findings. But she received more than a dozen rejections from journals -- mainly, she says, because the paper, co-authored with colleagues, involved self-experimentation. "The major concern was always ethical issues," says Halassy. She was particularly determined to persevere after she came across a review highlighting the value of self-experimentation.

That journals had concerns doesn't surprise Jacob Sherkow, a law and medicine researcher at the University of Illinois Urbana-Champaign who has examined the ethics of researcher self-experimentation in relation to COVID-19 vaccines. The problem is not that Halassy used self-experimentation as such, but that publishing her results could encourage others to reject conventional treatment and try something similar, says Sherkow. People with cancer can be particularly susceptible to trying unproven treatments. Yet, he notes, it's also important to ensure that the knowledge that comes from self-experimentation isn't lost. The paper emphasizes that self-medicating with cancer-fighting viruses "should not be the first approach" in the case of a cancer diagnosis.

"The majority of strokes could be prevented," reports the Associated Press, according to the first new guidelines in 10 years from the American Stroke Association, which are "aimed at helping people and their doctors do just that." Stroke was the fourth leading cause of death in the U.S. in 2023, according to the Centers for Disease Control and Prevention, and more than half a million Americans have a stroke every year. But up to 80% of strokes may be preventable with better nutrition, exercise and identification of risk factors... The good news is that the best way to reduce your risk for stroke is also the best way to reduce your risk for a whole host of health problems — eat a healthy diet, move your body and don't smoke...

Eating healthy can help control several factors that increase your risk for stroke, including high cholesterol, high blood sugar, and obesity, according to the heart association. The group recommends foods in the so-called Mediterranean diet such as fruits, vegetables, whole grains and olive oil, which can help keep cholesterol levels down. It suggests limiting red meat and other sources of saturated fat. Instead, get your protein from beans, nuts, poultry, fish and seafood. Limit highly processed foods and foods and drinks with a lot of added sugar. This can also reduce your calorie intake, which helps keep weight in check.

Getting up and walking around for at least 10 minutes a day can "drastically" reduce your risk, said Dr. Cheryl Bushnell, a neurologist at Wake Forest University School of Medicine who was part of the group that came up with the new guidelines. Among the many benefits: Regular exercise can help reduce blood pressure, a major risk factor for stroke. Of course, more is better: The heart association recommends at least 150 minutes of moderate aerobic or 75 minutes of vigorous activity — or some combination — per week. How you do it doesn't matter so much, experts said: Go to the gym, take a walk or run in your neighborhood or use treadmills or stepper machines at home. Diet and exercise can help control weight, another important risk factor for strokes.
But in addition, the guidelines now recommend that doctors consider new weight-loss drugs like Ozempic, Wegovy, Mounjaro and Zepbound for people with obesity or diabetes. (Though "people still need to eat well and get exercise, cautions Dr. Fadi Nahab, a stroke expert at Emory University Hospital.")

An anonymous reader quotes a report from the BBC: Police are on the hunt for 43 monkeys who escaped from a research facility in South Carolina, after a keeper left their pen open. The rhesus macaque fugitives broke out of Alpha Genesis, a company that breeds primates for medical testing and research, and are on the loose in a part of the state known as the Lowcountry. Authorities have urged residents to keep their doors and windows securely closed and to report any sightings immediately. The escaped monkeys are young females, weighing about 7lbs (3.2kg) each, according to the Yemassee Police Department. Police said on Thursday that the company had located the "skittish" group, and "are working to entice them with food."

"Please do not attempt to approach these animals under any circumstances," police said. The statement added that traps had been set in the area, and police were on-site "utilizing thermal-imaging cameras in an attempt to locate the animals". Police say the research company has told them that because of their size, the monkeys have not yet been tested on and "are too young to carry disease." In an update Friday, the local police department said the monkeys are still staying around the perimeter of the facility. "The primates are exhibiting calm and playful behavior, which is a positive indication," the department noted.

"They're just being goofy monkeys jumping back and forth playing with each other," Alpha Genesis CEO Greg Westergaard told CBS News Thursday. "It's kind of like a playground situation here."

The article points out that all the escaped monkeys "carry no contagious viruses because they were too young to test, according to the lab. "

Our bodies divest themselves of 60 billion cells every day through a natural process called "apoptosis". So Stanford medicine researchers are developing a new approach to cancer therapy that could "trick cancer cells into disposing of themselves," according to announcement from Stanford's medical school: Their method accomplishes this by artificially bringing together two proteins in such a way that the new compound switches on a set of cell death genes... One of these proteins, BCL6, when mutated, drives the blood cancer known as diffuse large cell B-cell lymphoma... [It] sits on DNA near apoptosis-promoting genes and keeps them switched off, helping the cancer cells retain their signature immortality.

The researchers developed a molecule that tethers BCL6 to a protein known as CDK9, which acts as an enzyme that catalyzes gene activation, in this case, switching on the set of apoptosis genes that BCL6 normally keeps off. "The idea is, Can you turn a cancer dependency into a cancer-killing signal?" asked Nathanael Gray, PhD, co-senior author with Crabtree, the Krishnan-Shah Family Professor and a chemical and systems biology professor. "You take something that the cancer is addicted to for its survival and you flip the script and make that be the very thing that kills it...."

When the team tested the molecule in diffuse large cell B-cell lymphoma cells in the lab, they found that it indeed killed the cancer cells with high potency. They also tested the molecule in healthy mice and found no obvious toxic side effects, even though the molecule killed off a specific category of of the animals' healthy B cells, a kind of immune cell, which also depend on BCL6. They're now testing the compound in mice with diffuse large B-cell lymphoma to gauge its ability to kill cancer in a living animal. Because the technique relies on the cells' natural supply of BCL6 and CDK9 proteins, it seems to be very specific for the lymphoma cells — the BCL6 protein is found only in this kind of lymphoma cell and in one specific kind of B cell. The researchers tested the molecule in 859 different kinds of cancer cells in the lab; the chimeric compound killed only diffuse large cell B-cell lymphoma cells.
Scientists have been trying to shut down cancer-driving proteins, one of the researchers says, but instead, "we're trying to use them to turn signaling on that, we hope, will prove beneficial for treatment."

The two researchers have co-founded the biotech startup Shenandoah Therapeutics, which "aims to further test this molecule and a similar, previously developed molecule," according to the article, "in hopes of gathering enough pre-clinical data to support launching clinical trials of the compounds.

"They also plan to build similar molecules that could target other cancer-driving proteins..."

Slashdot reader samleecole shared this report from 404 Media: Northwell Health, New York State's largest healthcare provider, recently launched a large language model tool that it is encouraging doctors and clinicians to use for translation, sensitive patient data, and has suggested it can be used for diagnostic purposes, 404 Media has learned. Northwell Health has more than 85,000 employees.

An internal presentation and employee chats obtained by 404 Media shows how healthcare professionals are using LLMs and chatbots to edit writing, make hiring decisions, do administrative tasks, and handle patient data. In the presentation given in August, Rebecca Kaul, senior vice president and chief of digital innovation and transformation at Northwell, along with a senior engineer, discussed the launch of the tool, called AI Hub, and gave a demonstration of how clinicians and researchers—or anyone with a Northwell email address—can use it... AI Hub can be used for "clinical or clinical adjacent" tasks, as well as answering questions about hospital policies and billing, writing job descriptions and editing writing, and summarizing electronic medical record excerpts and inputting patients' personally identifying and protected health information.

The demonstration also showed potential capabilities that included "detect pancreas cancer," and "parse HL7," a health data standard used to share electronic health records.

The leaked presentation shows that hospitals are increasingly using AI and LLMs to streamlining administrative tasks, and shows that some are experimenting with or at least considering how LLMs would be used in clinical settings or in interactions with patients.

An anonymous reader quotes a report from The Guardian: More than 50 US lawmakers are calling on the Environmental Protection Agency (EPA) to join dozens of other countries in banning a widely used weedkiller linked to Parkinson's disease and other health dangers. In a October 31 letter (PDF) to the agency, seven US senators said that paraquat, a weedkiller commonly applied on US farms, was a "highly toxic pesticide whose continued use cannot be justified given its harms to farmworkers and rural communities". The call for a ban from the senators came after 47 members of the US House of Representatives sent a similar letter (PDF) to the EPA calling for a ban earlier in October.

The lawmakers cite scientific links between paraquat use and development of Parkinson's and other "life threatening diseases" as well as "grave impacts on the environment". "Health risks include a higher risk of Parkinson's disease, with some studies finding a 64% increase in the likelihood of developing Parkinson's, non-Hodgkin's Lymphoma, thyroid cancer, and other thyroid issues," they wrote. The New Jersey senator Cory Booker, organizer of the Senate letter, said the risks of paraquat exposure were "well documented" and that it was "irresponsible" for the EPA to continue to allow its use. "I hope the EPA will follow the science and ban paraquat," Booker said. The EPA has long maintained that there is no "clear link" between paraquat exposure and Parkinson's disease, though the agency does have a number of restrictions on use of the chemical due to its acute toxicity. The agency issued a draft report earlier this year affirming its position. Still, the agency said at that time that it would be reviewing more scientific studies and would issue a final report by January 17, 2025.

A new study examining a large sample of privately insured patients with obesity found that use of drugs such as Ozempic and Wegovy as anti-obesity medications more than doubled from 2022 to 2023. During that same period, there was a 25.6% decrease in patients undergoing metabolic bariatric surgery to treat obesity. From a report: The study, by researchers at Brigham and Women's Hospital, in collaboration with researchers at Harvard T.H. Chan School of Public Health and the Brown School of Public Health, is published in JAMA Network Open. "Our study provides one of the first national estimates of the decline in utilization of bariatric metabolic surgery among privately insured patients corresponding to the rising use of blockbuster GLP-1 RA drugs," said senior author Thomas C. Tsai, a metabolic bariatric surgeon at Brigham and Women's Hospital.

Using a national sample of medical insurance claims data from more than 17 million privately insured adults, the researchers identified patients with a diagnosis of obesity without diabetes in 2022-2023. The study found a sharp increase in the share of patients who received glucagon-like peptide-1 receptor agonists, or GLP-1 RAs, during the study period, with GLP-1 RA use increasing 132.6% from the last six months of 2022 to the last six months of 2023 (from 1.89 to 4.41 patients per 1,000 patients).

Meanwhile, there was a 25.6% decrease in use of bariatric metabolic surgery during the same period (from 0.22 to 0.16 patients per 1,000 patients). Among the sample of patients with obesity, 94.7% received neither form of treatment during the study period (while 5% received GLP-1 RAs and 0.3% received surgery). Compared to patients who were prescribed GLP-1 RAs, patients who underwent surgery tended to be more medically complex.