AI

Hospitals Deploy AI Tools To Detect COVID-19 on Chest Scans (ieee.org) 16

Deep learning algorithms can diagnose, triage, and monitor coronavirus cases from lung images. Next, can they predict who will need a ventilator? From a report: AI-powered analysis of chest scans has the potential to alleviate the growing burden on radiologists, who must review and prioritize a rising number of patient chest scans each day, experts say. And in the future, the technology might help predict which patients are most likely to need a ventilator or medication, and which can be sent home. "That's the brass ring," says Matthew Lungren, a pediatric radiologist at Stanford University Medical Center and co-director of the Stanford Center for Artificial Intelligence in Medicine and Imaging. "That would be the killer app for this." Some companies are selling their tools, others have released free online versions, and various groups are organizing large crowdsourced repositories of medical images to generate new algorithms. "The system we designed can process huge amounts of CT scans per day," says Hayit Greenspan, a professor at Tel-Aviv University and chief scientist of RADLogics, a healthcare software company that recently announced one such AI-based system. "The capability for quickly covering a huge population is there."
Republicans

Trump Threatens To Withhold Funding For World Health Organization (nytimes.com) 641

What better way to celebrate World Health Day than by threatening to withhold funding for the World Health Organization. That's exactly what President Trump said he was considering today at Tuesday's coronavirus press briefing. The New York Times reports: "We're going to put a hold on money spent to the W.H.O.; we're going to put a very powerful hold on it and we're going to see," Mr. Trump said, accusing the organization of having not been aggressive enough in confronting the dangers from the virus. "They called it wrong. They call it wrong. They really they missed the call." Mr. Trump appeared to be particularly angry at the W.H.O. for issuing a statement saying it did not support his decision on Jan. 31 to restrict some travel from China because of the virus. At the time, the group issued a statement saying that "restricting the movement of people and goods during public health emergencies is ineffective in most situations and may divert resources from other interventions."

"Don't close your borders to China, don't do this," Mr. Trump said, paraphrasing the group and accusing the organization of "not seeing" the outbreak when it started in Wuhan, China. "They didn't see it, how do you not see it? They didn't see it. They didn't report it. If they did see it, they must have seen it, but they didn't report." In fact, the W.H.O. repeatedly issued statements about the emergence of the virus in China and its movement around the world.
The budget for the W.H.O. is about $5 billion and comes from member countries around the world. "In 2017, the last year for which figures were available, the United States was required to spend $111 million based on the organization's rules, but sent an additional $401 million in voluntary contributions," reports The New York Times.

Trump said his government will investigate the organization and that "we will look at ending funding." It's unclear if he's planning to eliminate all funding, or only some.
Medicine

New Research Links Air Pollution To Higher Coronavirus Death Rates (nytimes.com) 81

Coronavirus patients in areas that had high levels of air pollution before the pandemic are more likely to die from the infection than patients in cleaner parts of the country, according to a new nationwide study that offers the first clear link between long-term exposure to pollution and Covid-19 death rates. From a report: In an analysis of 3,080 counties in the United States, researchers at the Harvard University T.H. Chan School of Public Health found that higher levels of the tiny, dangerous particles in air known as PM 2.5 were associated with higher death rates from the disease. For weeks, public health officials have surmised a link between dirty air and death or serious illness from Covid-19, which is caused by the coronavirus. The Harvard analysis is the first nationwide study to show a statistical link, revealing a "large overlap" between Covid-19 deaths and other diseases associated with long-term exposure to fine particulate matter. "The results of this paper suggest that long-term exposure to air pollution increases vulnerability to experiencing the most severe Covid-19 outcomes," the authors wrote.
Medicine

Supervised Self-Driving Shuttles Are Moving COVID-19 Tests In Florida (theverge.com) 20

Autonomous shuttles are being used to move COVID-19 tests from a Jacksonville, Florida testing site to a nearby Mayo Clinic processing location, in what the medical nonprofit is calling a "first" for the U.S. But as is often the case with autonomous vehicle pilot programs, there's a catch: during each run made to and from the clinic, the self-driving shuttles are being trailed by an SUV driven by a human. The Verge reports: The SUV can be spotted in a video released by the Mayo Clinic, after one of the Mayo Clinic workers loads the cooler of tests onto the self-driving shuttle. The SUV then follows the shuttle across the Mayo Clinic's campus, where the batch of fresh tests is swapped for another cooler. Four of these vehicles have made the same run back and forth each day since March 30th. In a statement provided to The Verge, Joe Moye, the CEO of autonomous vehicle operator Beep, said the Jacksonville Transportation Authority is providing the chase vehicles to "ensure no traffic or pedestrians would potentially impact the delivery path of the COVID-19 samples and supplies." That's despite the fact that the Mayo Clinic's press release says the routes the shuttles are running "are isolated from pedestrians, traffic and staff."

A representative for Beep, which worked with the Mayo Clinic, JTA, and self-driving shuttle builder Navya on the pilot, says that putting the tests in the attendant-less shuttle instead of in an SUV or truck being driven by a human helps limit any potential exposure to the novel coronavirus. And judging from the distance covered in the video released by the Mayo Clinic, it does look like using some sort of vehicle -- autonomous or not -- would indeed help speed up the delivery of the tests to the processing site. Another benefit, according to Moye, is that the shuttle helps keep many Mayo Clinic staff as free as possible, since they would otherwise have to transport the samples themselves.

Medicine

UK Prime Minister Boris Johnson Taken To Intensive Care For Coronavirus Treatment (bloomberg.com) 405

Boris Johnson has been taken into the hospital intensive care unit for treatment for coronavirus after his condition worsened, his office said. The Guardian reports: The British prime minister was admitted to St Thomas's Hospital in London on Sunday night because his virus symptoms had not cleared up and he became more seriously ill on Monday afternoon, a government spokesperson said in an email. "Over the course of this afternoon, the condition of the prime minister has worsened and, on the advice of his medical team, he has been moved to the intensive care unit at the hospital," according to the statement. Foreign Secretary Dominic Raab will stand in for Johnson running the country, "where necessary." Mr. Johnson was confirmed to have coronavirus last Thursday, becoming the first Western leader known to have contracted the disease. On Sunday evening, Johnson was admitted to the hospital as a "precautionary step," according to his Downing Street Office.
Medicine

A Google Plan To Wipe Out Mosquitoes Appears to Be Working (bloomberg.com) 88

An experimental program led by Google parent Alphabet to wipe out disease-causing mosquitoes succeeded in nearly eliminating them from three test sites in California's Central Valley. From a report: Stamping out illness caused by mosquitoes is one of Alphabet unit Verily's most ambitious public-health projects. The effort appears to be paying off, according to a paper published in the journal Nature Biotechnology on Monday. Verily is also running coronavirus triage and testing in parts of California. Bradley White, the lead scientist on the Debug initiative, said mosquito-suppression is even more important during the pandemic, so that outbreaks of mosquito-borne diseases such as dengue fever don't further overwhelm hospitals.

Since 2017, the company has released millions of lab-bred Aedes aegypti male mosquitoes into several Fresno County neighborhoods during mosquito season. The insects are bred in Verily labs to be infected with a common bacterium called Wolbachia. When these male mosquitoes mate with females in the wild, the offspring never hatch. In results of the trial published on Monday, Verily revealed that throughout the peak of the 2018 mosquito season, from July to October, Wolbachia-infected males successfully suppressed more than 93% of the female mosquito population at field test sites. Only female mosquitoes typically bite.

Medicine

Bill Gates To Spend Billions on Coronavirus Vaccine Development (wsj.com) 113

Microsoft co-founder Bill Gates said his foundation will spend billions of dollars to fund the construction of factories for the most promising efforts to develop a vaccine to combat the novel coronavirus. From a report: Mr. Gates, a billionaire philanthropist who is one the richest people in the world, said the Bill and Melinda Gates Foundation will work with seven makers of a possible vaccine to build these factories. Mr. Gates, who announced the efforts in an appearance on "The Daily Show With Trevor Noah" Thursday, acknowledged that billions of dollars would be wasted on vaccines that won't pan out. "Our early money can accelerate things," Mr. Gates said. "Even though we'll end up picking at most two of them, we're going to fund factories for all seven, just so that we don't waste time in serially saying which vaccine works and then building the factory."
Biotech

Apple Begins Making Millions of Face Shields and Sources 20 Million Face Masks (cnet.com) 40

"Apple announced Sunday it's launched a companywide effort to design, produce and ship face shields to medical workers battling the coronavirus outbreak," reports CNET: The first shipment was delivered this week to a Kaiser facility in the Santa Clara Valley, Apple CEO Tim Cook said in a video posted to Twitter.

"Teams across Apple have been working hard on ways we can support our heroic front-line medical professionals," Cook said, explaining that the fully adjustable shields pack flat and can be assembled in two minutes. "The feedback from doctors was very positive." "We plan to ship over 1 million by the end of this week, and over 1 million per week after that," he said. Cook said the company is coordinating with health and government officials across the US to get the shields delivered where they're needed and hopes to expand distribution beyond the US quickly.

"Apple is dedicated to supporting the worldwide response to COVID-19," Apple's CEO said on Twitter. "We've now sourced over 20M masks through our supply chain."
Medicine

How Robert Cringely Scored 5 Million N95 Masks From China (cringely.com) 99

This week, tech pundit Robert Cringely described how a chance conversation with China-based entrepreneur Anina led to a friend with a garment factory "now making fully certified N-95 respirators with no clear distribution plan." Late on a Sunday night with the tech world in shut-down, how long would it take for me to find someone looking for up to five million N-95 masks? It took 10 minutes.

I reached out to Salesforce.com CEO Marc Benioff and to Mark Cuban from the Dallas Mavericks and Shark Tank... Mark Cuban put me in touch with ProjectN95, a just-created national clearinghouse for urgently needed medical equipment... It's important to realize what a miracle we accomplished. Normally there are lots of middlemen in Chinese distribution, but in this case, there were none, which meant maximal speed and minimal price. The goods were U.S. FDA certified, too, and the certification could be verified...

We are tech people attempting to function during a pandemic, but what really counted here were personal relationships. Anina knows and trusts the factory owner. Anina and I have known each other for 15 years and I've known Marc Benioff and Mark Cuban even longer. We spend billions as a culture trying to build digital versions of such webs of trust, but sometimes it is better to do it the old fashion way.

Medicine

Stanford Begins America's First Large-Scale Test For Coronavirus Antibodies (eastbaytimes.com) 82

"Crowds flock to Santa Clara County test sites to learn if they have antibodies to COVID-19," reports the Bay Area Newsgroup, citing long lines of cars forming at three Stanford research sites for the drive-through tests: The 2,500 test slots on Friday and Saturday filled up within hours, as news of the project -- the first large scale study of its type in the U.S. -- spread quickly through the county. The test detects protective antibodies to the virus rather than the virus itself. This gives scientists a snapshot of how many people in the county have already been infected, but weren't seriously sick and didn't realize it. And it tells residents whether they carry potentially protective antibodies -- so may be immune to future infection. "This is critical information," said principal investigator Dr. Eran Bendavid, an infectious disease specialist and professor of medicine with Stanford Health Policy.

"We will show the country what to do and how to do it," he said... It can guide public health measures and policies -- showing where the epidemic is heading, when it is safe to lift shelter-in-place restrictions and how far away we are from "herd immunity," when it becomes harder for a virus to spread...

This approach, called a "serological test," remains a research tool and is not yet widely available in the United States. Stanford is working on a second test that will be deployed for more widespread use. U.S. Food and Drug Administration approval is imminent -- "within hours, not days," [California governor] Newsom said.... Meanwhile, a global effort to study antibodies is being coordinated by the World Health Organization. Called Solidarity II, more than a half dozen countries will pool their findings from large-scale testing...

It is not yet proven that these antibodies actually provide protection... But there are promising clues that COVID-19 might act like it's closest cousin, the SARS virus, which triggers an immune response that persists for at least three years. In a Chinese study of rhesus monkeys, COVID-19 antibodies protected the animals from a second infection.

If protected, people could potentially return to work. There is also the prospect that the antibodies could be used as therapy against the disease. Dozens of companies are working to develop antibody tests, as are researchers at the Centers for Disease Control and Prevention.

The article notes that United Biomedical Inc will "soon" also provide free antibody testing to all 8,000 residents in Telluride, Colorado, and in some countries in Asia.
Medicine

Why Taiwan's Coronavirus Response Is Among The Best Globally (cnn.com) 157

Why does Taiwan have less than 400 confirmed cases of Covid-19? Taiwan's experience with the 2003 SARS outbreak "helped many parts of the region react faster to the current coronavirus outbreak and take the danger more seriously than in other parts of the world," reports CNN, "both at a governmental and societal level, with border controls and the wearing of face masks quickly becoming routine as early as January in many areas."

Their article also notes that Taiwan "has a world-class health care system, with universal coverage," which drew praise in new report published in the Journal of the American Medical Association: "Taiwan rapidly produced and implemented a list of at least 124 action items in the past five weeks to protect public health," report co-author Jason Wang, a Taiwanese doctor and associate professor of pediatrics at Stanford Medicine, said in a statement. "The policies and actions go beyond border control because they recognized that that wasn't enough." This was while other countries were still debating whether to take action. In a study conducted in January, Johns Hopkins University said Taiwan was one of the most at-risk areas outside of mainland China -- owing to its close proximity, ties and transport links.

Among those early decisive measures was the decision to ban travel from many parts of China, stop cruise ships docking at the island's ports, and introduce strict punishments for anyone found breaching home quarantine orders. In addition, Taiwanese officials also moved to ramp up domestic face-mask production to ensure the local supply, rolled out island-wide testing for coronavirus -- including re-testing people who had previously unexplained pneumonia -- and announced new punishments for spreading disinformation about the virus.

"Given the continual spread of Covid-19 around the world, understanding the action items that were implemented quickly in Taiwan, and the effectiveness of these actions in preventing a large-scale epidemic, may be instructive for other countries," Wang and his co-authors wrote.... Taiwan is in such a strong position now that, after weeks of banning the export of face masks in order to ensure the domestic supply, the government said Wednesday that it would donate 10 million masks to the United States, Italy, Spain and nine other European countries, as well as smaller nations who have diplomatic ties with the island.

IBM

IBM is Deploying Its Watson AI to Help Governments Answer People's Covid-19 Questions (digitaltrends.com) 25

Digital Trends reports: IBM's question-answering Watson A.I. is most famous for whooping the butt of human champions on quiz show Jeopardy. Now, IBM has repurposed its famous creation to help government agencies, health care organizations, and academic institutions around the world cope with the massive overload of questions that citizens have about the COVID-19 pandemic.

This is the first time that Watson has been used to help in a pandemic scenario.

A coronavirus-focused version of the Watson A.I. has been called into service as a virtual agent in places including Arkansas, California, Georgia, New York, and Texas in the United States, as well as the Czech Republic, Greece, Poland, Spain and U.K. It is capable of answering locally relevant questions, ranging from those about coronavirus symptoms and testing specifics to queries on things like social distancing. These consistent and accurate responses can be provided to citizens via voice calls or text chat...

Watson Assistant for Citizens pulls data from a range of external sources — local, national, and international.

Digital Trends got an interesting response from one consultant at IBM Watson Health who's an expert on digital health for the World Health Organization. "Our team is currently adding responses to psychological questions, by which a virtual nurse can help people to deal with their fears and emotional problems and provide comfort to them in these times."
United States

The Story of The Doctor Who Ordered America's First Covid-19 Lockdown (mercurynews.com) 164

Long-time Slashdot reader bsharma shared the story of doctor/public health officer who "went first," ordering America's very first coronavirus lockdown in six counties on March 16th after the identification of only the 7th known case of Covid-19 in the United States.

The Bay Area Newsgroup reports that on January 31st, Cody's cellphone rang at 6:49 a.m. "You've got your first positive," the voice said. Right then, Cody — Santa Clara County's Public Health Officer since 2013 — was positive that even by Silicon Valley standards, life as we know it here was about to change....

Back in the early 2000s, with the country on edge after 9/11, Cody, Karen Smith and Marty Fenstersheib led the health department's effort to build Santa Clara County's model for a massive, coordinated emergency response to a bioterrorism attack or pandemic that included social distancing, shutting schools and the most extreme, mandating that people stay home. It's the one they would turn to this month to slow the untraceable path of this new disease known as COVID-19. "None of us really believed we would do it," Smith, 63, said in a recent interview. "I was slightly terrified to think we were putting in place stay-at-home orders, tools that we think work but don't really know...."

Through the years, Cody has learned that public health officers never have all the information they need and are always operating with uncertainty. But the stakes are so much higher now. The second confirmed case of coronavirus in the county came 48 hours after the first; both were travelers from China. But the criteria for sending swabs for testing to the U.S. Centers for Disease Control and Prevention in Atlanta was so stringent and the bottleneck for test results so long, that the county was left hamstrung trying to figure out how big of a problem it really had. Not until nearly a month later, on Feb. 28, two days after the county was finally given authorization to use its own lab and judgment for testing, was the third "positive" confirmed.

It would be a "sentinel case" — a turning point for the virus' spread across the Bay Area — a woman in her 60s with other health conditions. Unlike the first two, this was a clear case of "community transmission," meaning the woman had become infected somewhere in our community, with no clear connection to a traveler. "In very short order," Cody said, "it became apparent we needed to start scaling up fast...." By March 9, the sick woman in her 60s — the sentinel case — had died, and 43 cases had been confirmed, the highest of any county in California. Santa Clara County would now be branded across the country as a coronavirus "hot zone...."

"It was clear to me already how quickly it was moving, and that's what gave me a sense of urgency," Cody said. "We just needed to embrace the risk and do it."

"I recognize that this is unprecedented," Cody said in announcing the lockdown. "But we must come together to do this and we know we need a regional response... We must all do our part to slow the spread of COVID-19."

A professor of epidemiology at the University of California San Francisco has told the same newspaper "That's going to turn out to be — if all goes well and I'm reading the tea leaves right — one of the major public health triumphs of modern times." That article reports that while California had roughly the same number of cases as New York in the first week of March, "by the end of the month, New York had 75,795 cases while California had a tenth of that — 7,482."

An infectious disease doctor (and associate executive director with Permanente Medical Group) also told Politico Tuesday that at Kaiser Permanente hospitals across Northern California, they're "seeing a leveling off of Covid-19 cases in our hospitals." And one writer even quoted an emergency room doctor at the UCSF hospital who said last weekend they'd seen less than half the normal number of emergency room patients, and "My colleagues at Stanford, as well as at other facilities in San Francisco report much of the same conditions in their hospitals...

"It seems very likely, that the 'shelter in place' policy has had a significant, positive effect on containing the spread of COVID-19 in the Bay Area."
Medicine

Snopes Disputes 'Shakiness' of COVID-19 Origin Story Claimed By Washington Post OpEd (snopes.com) 238

Thursday an Opinion piece in the Washington Post touted what the paper's own health policy reporter has described as "a conspiracy theory that has been repeatedly debunked by experts." That conspiracy theory argues that instead of originating in the wild, the COVID-19 virus somehow escaped from a research lab.

Now the fact-checking web site Snopes has also weighed in this week, pointing out that the lab nearest the Wuhan market hadn't even published any coronavirus-related research prior to the outbreak. Instead the nearest coronavirus-researching lab was about 7 miles away, a maximum security "biosafety level 4 (BSL-4) laboratory certified to handle the world's most deadly pathogens." A February 2020 document erroneously described by several media outlets as a "scientific study" provides the supposedly science-based evidence of a virus escaping from a lab. This paper, such as it is, merely highlights the close distance between the seafood market and the labs and falsely claimed to have identified instances in which viral agents had escaped from Wuhan biological laboratories in the past... While SARS viruses have escaped from a Beijing lab on at least four occasions, no such event has been documented in Wuhan.

The purported instances of pathogens leaking from Wuhan laboratories, according to this "study," came from a Chinese news report (that we believe, based on the similarity of the research described and people involved, to be reproduced here) that profiled a Wuhan Center for Disease Control and Prevention researcher named Tian Junhua. In 2012 and 2013, he captured and sampled nearly 10,000 bats in an effort to decode the evolutionary history of the hantavirus. In two instances, this researcher properly self-quarantined either after being bitten or urinated on by a potentially infected bat, he told reporters. These events, according to the 2013 study his research produced, occurred in the field and have nothing to do with either lab's ability to contain infective agents...

In sum, this paper -- which was first posted on and later deleted from the academic social networking website ResearchGate -- adds nothing but misinformation to the debate regarding the origins of the novel coronavirus and is not a real scientific study.

In February the Washington Post had quoted Vipin Narang, an associate professor at the Massachusetts Institute of Technology, as saying that it's "highly unlikely" the general population was exposed to a virus through an accident at a lab. "We don't have any evidence for that," said Narang, a political science professor with a background in chemical engineering.

UPDATE: On Twitter Snopes' reporter has identified what he sees as major errors in the Post's recently-published op-ed.
Transportation

Y Combinator Company 'Flexport' Is Shipping PPE To Frontline Responders (gofundme.com) 37

The Y Combinator company Flexport is a San Francisco-based freight-forwarding and customs brokerage company. (Its investors include Google Ventures and Peter Thiel's Founders Fund.) But on March 23rd Flexport announced they were now re-focusing all their resources to get critical supplies to frontline responders combating COVID-19.

They've joined a team that announced on Friday announced "we're shipping full cargo planes filled with PPE to protect frontline responders," citing a partnership with Atlas Air and United Airlines. Atlas Air delivered a dedicated charter plane for this mission on Thursday, April 2nd. Originating in Shanghai, the plane contained over 143,000 pounds of PPE for medical systems in California, including approximately:

- 4,500,000 medical masks
- 116,000 disposable medical protection coveralls
- 121,300 surgical gowns

For this volume of goods, significant capacity is needed on a plane. However, global travel has plunged because of the outbreak, meaning that passenger planes which used to carry cargo are grounded, and the air market capacity is extremely limited. And hospitals, who in normal situations aren't importing their own goods, can't arrange cargo on a plane on their own...

Crews from United Airlines volunteered to help, arriving at SFO [San Francisco International Airport] at 6AM to unload and unpack the plane. The cargo was then put on a truck and delivered directly to hospitals that will distribute the PPE across the state based on need...

Up next, we're moving cargo to New York and will share updates next week. Please continue to help us spread the word to support the response efforts.

They're raising money on GoFundMe, and this "Frontline Responders Fund" has so far raised over $6 million from 15,800 donors. Their page notes that on Thursday former California governor Arnold Schwarzenegger "personally helped us deliver a trucking shipment from MedShare with 49,000 donated masks to a hospital in Los Angeles, California."

Their page also notes donations have funded the trucking of goods across America from nonprofits, including:
  • All Hands and All Hearts Smart Response, who delivered over 43,000 units of gloves, gowns, face masks, goggles, and hand sanitizer to emergency rooms and hospitals in New York City and Southern California.
  • Donate PPE, who delivered over 3,750 N95 respirator masks to hospitals in Brooklyn, NY yesterday

One of their supporters is actor Clark Gregg, who plays agent Coulson in five Marvel movies and the TV series Agents of S.H.I.E.L.D. He records personalized video greetings for fans through a web site called Cameo, and through Wednesday he donated 100% of the money earned to the Frontline Responders Fund.


The Internet

Vint Cerf 'No Longer Contagious' With Covid-19 (twitter.com) 37

DevNull127 writes: Good news — VA Public Health has certified my wife and me as no longer contagious with COVID19," tweeted 76-year-old Vint Cerf, one of the creators of the modern internet.

He added one word. "Recovering!"

It seemed especially appropriate that Cerf shared his news online — and that it drew positive responses from grateful people around the world, including several who use the internet in their daily lives. Cerf's tweet immediately drew positive responses from the Internet Society, as well as the chief operating officer of the Cloud Native Computing Foundation, YouTube's director of public policy, and a senior director of communications and public affairs at Google. There were also congratulatory posts from a Georgetown professor of technology and law, from Associated Press reporter Frank Bajak, and the executive director of the Global Privacy and Security by Design Centre.

Cerf followed up his news with a re-tweet of Google's "Community Mobility Reports" charting our aggregate movement trends over time, and a tweet of a University of Pittsburgh press release about progress on a COVID-19 vaccine candidate.

Earlier in the week Cerf also re-tweeted a humorous compilation of clips from the TV show M*A*S*H that illustrated safe practices while social distancing.

Medicine

Potential Vaccine Generates Enough Antibodies To Fight Off Virus (independent.co.uk) 120

Slashdot readers schwit1 and Futurepower(R) are sharing news about a potential coronavirus vaccine that has been found to produce antibodies capable of fighting off Covid-19. The Independent reports: The vaccine, which was tested on mice by researchers at the University of Pittsburgh School of Medicine, generated the antibodies in quantities thought to be enough to "neutralize" the virus within two weeks of injection. The study's authors are now set to apply to the U.S. Food and Drug Administration for investigational new drug approval ahead of phase one human clinical trials planned to start in the next few months. [T]he Pittsburgh research is the first study on a Covid-19 vaccine candidate to be published after review from fellow scientists at outside institutions. The scientists were able to act quickly because they had already laid the groundwork during earlier epidemics of coronaviruses: Sars in 2003 and Mers in 2014. What's also neat about this potential vaccine is that it can sit at room temperature until it is needed and be scaled up to produce the protein on an industrial scale.

The fingertip-sized patch of 400 tiny microneedles "inject the spike protein pieces into the skin, where the immune reaction is strongest," the report says. "The patch is stuck on like a plaster and the needles -- which are made entirely of sugar and the protein pieces -- simply dissolve into the skin." While long-term testing is still required, "the mice who were given the Pittsburgh researchers' Mers vaccine candidate developed enough antibodies to neutralize the virus for at least a year," reports The Independent. "The antibody levels of the rodents vaccinated against Covid-19 'seem to be following the same trend,' according to the researchers."
Medicine

Trump: CDC Recommends Cloth Face Covering To Protect Against Coronavirus 145

President Trump says the CDC now recommends using a cloth face covering to protect against coronavirus, but said he does not plan to do so himself. CNBC reports: Trump stressed that the recommendations were merely voluntary, not required. "I don't think I'm going to be doing it" he said as he announced the new guidance. The CDC's website explained that the recommendations were updated following new studies that some infected people can transmit the coronavirus even without displaying symptoms of the disease.
"In light of this new evidence, CDC recommends wearing cloth face coverings in public settings where other social distancing measures are difficult to maintain," such as in grocery stores or pharmacies, "especially in areas of significant community-based transmission," the CDC says.
Developing...
Medicine

Hospital Autoclaves May Allow Safe Reuse of N95 Masks (www.cbc.ca) 71

Freshly Exhumed shares a report from CBC.ca: "[Autoclaving] is like a pressure cooker -- basically you enclose items into a chamber, you lock down the chamber, you heat it up and actually increase the pressure inside the chamber," Dr. Anand Kumar, a professor of medicine at the University of Manitoba, said. The machines heat up to about 121 C for 15 minutes, killing bacteria and viruses. "It'll sterilize anything." The assumption has been that if you tried this on an N95 mask they would degrade rapidly. We thought we'd give it a try anyway," Kumar said. "And actually what we found is while it does degrade some [types of] masks, there's a certain group of masks that are made of kind of a fabric-type material, rather than being moulded closely to the face they're called pleated [masks]," he said. Kumar said the pleated fabric masks can be cycled through an autoclaving machine 10 times and come out as good as before.

"The reason this is really important is that autoclaves are available at literally every established hospital in the world. There is probably no hospital in the world that doesn't have an autoclave machine," Kumar said. "So everybody can use this for these particular types of masks and these particular types of masks are probably the most common type of N95 mask, so we're really pleased." Kumar said the technique could be put into use at any hospital at any time. "It's a technology that's available and ready to go right now."

Medicine

The World Just Hit 1 Million Coronavirus Infections (bloomberg.com) 305

The new coronavirus has now infected 1 million people across the world, a milestone reached just four months after it first surfaced in the Chinese city of Wuhan. More than 51,000 have died and 208,000 recovered in what has become the biggest global public health crisis of our time. Bloomberg reports: When the virus was first discovered, doctors likened it to Severe Acute Respiratory Syndrome, or SARS, the illness that sickened 8,000 people mostly in Asia in 2003. Highly contagious, and appearing with little or no symptoms in some cases, Covid-19 has rapidly eclipsed all recent outbreaks in scale and size. Fewer than 20 countries in the world remain free of infection. With some virus carriers presenting few outward signs of illness, and many countries unable or unwilling to conduct wider testing, the true number of global infections is likely higher -- some say far higher -- than 1 million.

The U.S. now has the most cases officially recorded globally with more than 234,000, according to Johns Hopkins University, which draws on a combination of data sources -- from governments to the World Health Organization and local media -- to feed its tallies. Next is Italy, with 115,000, the JHU data show. Italy has the highest death toll with almost 14,000 virus fatalities, followed by Spain. With world travel paralyzed and millions of people under some form of lockdown as a result of government efforts to contain the spread, the health crisis has also become an economic one: The global economy is expected to shrink 2% in the first half of 2020. Business activity has ground to a halt in many sectors, with predictions the U.S. jobless rate could reach 30% in the second quarter.

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