At least 759 US hospitals experienced network disruptions during the CrowdStrike outage on July 19, 2024, with more than 200 suffering outages that directly affected patient care services, according to a study published in JAMA Network Open by UC San Diego researchers. The researchers detected disruptions across 34% of the 2,232 hospital networks they scanned, finding outages in health records systems, fetal monitoring equipment, medical imaging storage, and patient transfer platforms.

Most services recovered within six hours, though some remained offline for more than 48 hours. CrowdStrike dismissed the study as "junk science," arguing the researchers failed to verify whether affected networks actually ran CrowdStrike software. The researchers defended their methodology, noting they could scan only about one-third of America's hospitals, suggesting the actual impact may have been significantly larger.

"Eight healthy babies were born in Britain," reports Phys.org, "with the help of an experimental technique that uses DNA from three people to help mothers avoid passing devastating rare diseases to their children, researchers reported Wednesday."

Mutations in mitochondrial DNA "can cause a range of diseases in children that can lead to muscle weakness, seizures, developmental delays, major organ failure and death," and in rare cases even pre-IVF testing can't clearly detect their presence. Researchers have been developing a technique that tries to avoid the problem by using the healthy mitochondria from a donor egg. They reported in 2023 that the first babies had been born using this method... Using this method means the embryo has DNA from three people — from the mother's egg, the father's sperm and the donor's mitochondria — and it required a 2016 U.K. law change to approve it. It is also allowed in Australia but not in many other countries, including the U.S. Experts at Britain's Newcastle University and Monash University in Australia reported in the New England Journal of Medicine Wednesday that they performed the new technique in fertilized embryos from 22 patients, which resulted in eight babies that appear to be free of mitochondrial diseases. One woman is still pregnant...

Robin Lovell-Badge [a stem cell and developmental genetics scientist at the Francis Crick Institute who was not involved in the research] said the amount of DNA from the donor is insignificant, noting that any resulting child would have no traits from the woman who donated the healthy mitochondria...

In the U.K., every couple seeking a baby born through donated mitochondria must be approved by the country's fertility regulator. As of this month, 35 patients have been authorized to undergo the technique. Critics have previously raised concerns, warning that it's impossible to know the impact these sorts of novel techniques might have on future generations... But in countries where the technique is allowed, advocates say it could provide a promising alternative for some families.

Cancer death rates in the U.S. have fallen by approximately one-third since the 1990s when adjusted for age, according to data cited in a new analysis of global cancer trends. The decline represents a steady, year-over-year reduction that began in the early 1990s and continues across developed countries.

Prevention efforts have contributed substantially to the decline. Reduced smoking rates in wealthy nations prevented more than 3 million cancer deaths since 1975 in America alone. Britain's HPV vaccination program, launched in 2008 for teenage girls, produced a 90% reduction in cervical cancer rates among women in their 20s within 15 years. Treatment advances have transformed outcomes for specific cancers. Childhood leukemia, once virtually fatal, now has a five-year survival rate above 90%.

Researchers have identified inexpensive drugs with cancer-prevention properties, including aspirin, which cuts bowel cancer risk in half for patients with Lynch syndrome. Future progress faces obstacles, however, including high treatment costs and planned cuts to the National Cancer Institute under the Trump administration. China overtook America as the primary source of cancer research in 2025.

Researchers have created the world's first mRNA-based vaccine against a deadly, antibiotic-resistant bacterium — and they did it using the platform developed for COVID-19 vaccines.

Medical Express publishes their announcement: The vaccine developed by the team from the Institute for Biological Research and Tel Aviv University is an mRNA-based vaccine delivered via lipid nanoparticles, similar to the COVID-19 vaccine. However, mRNA vaccines are typically effective against viruses like COVID-19 — not against bacteria like the plague... In 2023, the researchers developed a unique method for producing the bacterial protein within a human cell in a way that prompts the immune system to recognize it as a genuine bacterial protein and thus learn to defend against it.

The researchers from Tel Aviv University and the Institute for Biological Research proved, for the first time, that it is possible to develop an effective mRNA vaccine against bacteria. They chose Yersinia pestis, the bacterium that causes bubonic plague — a disease responsible for deadly pandemics throughout human history. In animal models, the researchers demonstrated that it is possible to effectively vaccinate against the disease with a single dose.
The team of researchers was led by Professor Dan Peer at Tel Aviv University, a global pioneer in mRNA drug development, who says the success of the current study now "paves the way for a whole world of mRNA-based vaccines against other deadly bacteria."

James Gunn's Superman "appears to be succeeding in rebooting DC Studios and its most iconic comic book franchise," writes The Hollywood Reporter, noting the film is "headed for a possible record domestic box office debut of $115 million to $120 million." Gunn is in a unique position, being both the film's writer-director and the co-head of the Warner Bros.-owned DC, which he co-runs with Peter Safran. Overseas, Superman is launching to $100 million-plus from 78 markets after earning $40 million midweek from its first raft of international markets for an early global total of $96.5 million through Friday. Superman will be the first superhero film to cross $100 million in its North American bow since Marvel Studios and Ryan Reynolds' Deadpool & Wolverine launched to $211 million in summer 2024 ("superhero fatigue" has become part of the Hollywood lexicon). And it's the first DC title to cross $100 million in eight long years since Wonder Woman debuted to $103.3 million in 2017.

And if the $225 million tentpole comes in north of $116.6 million, it will beat Zack Snyder's 2013 film Man of Steel ($116.7 million) to rank as the biggest domestic launch ever for a solo Superman pic, not adjusted for inflation. Snyder's mash-up Batman v Superman: Dawn of Justice scored the biggest DC opening of all time when earning $166.6 million over Easter weekend in 2016... Gunn's movie is only the third Hollywood title of 2025 to launch north of $100 million after fellow Warners tentpole A Minecraft Movie, which opened to $162.8 million, and Disney's live-action Lilo & Stitch, which sewed up $146 million in its debut. Crossing the century mark is no small feat for any movie in the post-pandemic era, and particularly for the troubled superhero genre.

The pic should enjoy a long run thanks to strong word-of-mouth. Critics and audiences alike are embracing the film. The pic earned an A- CinemaScore from moviegoers, the same grade given to Man of Steel and ahead of Superman Returns' B+. The audience score on Rotten Tomatoes is a stellar 94 percent, while the critics' score is a pleasing 82 percent...

Other upcoming DC Studios projects include HBO's Green Lantern series, Lanterns, and a Supergirl movie due out in 2026.
Superman's weekend debut at nearly $130 million domestically smashes early estimates of around $90 million (according to a senior media analyst at Comscore).

And the film also got a positive reaction from the author of the cultural history Superman: The Unauthorized Biography (writing for NPR): Recent attempts to tell live-action Superman stories have shied away from his bright, hopeful, altruistic nature in favor of making him more cool and relatable (read: dark and brooding). That's not who he is; it never has been. Superman is an ideal. He represents the best we can aspire to be. He's not the hero you relate to, à la Peter Parker/Spider-Man's ongoing struggle to pay his rent and buy Aunt May her damn medicine. He's the hero who inspires you, who shows you the way...

It doesn't have to be about slogging through trauma and shame and shadow-selves and endlessly tedious redemption arcs. Sometimes, it's simpler, cleaner, brighter. And also? Not for nothing? More fun.

It killed tens of millions of people in 14th century Europe," CNN reports, though "today, it's easily treated with antibiotics."

And yet "A resident of northern Arizona has died from pneumonic plague, health officials said Friday." Plague is rare to humans, with on average about seven cases reported annually in the U.S., most of them in the western states, according to federal health officials. The death in Coconino County, which includes Flagstaff, was the first recorded death from pneumonic plague since 2007, local officials said... The bubonic plague is the most common form of the bacterial infection, which spreads naturally among rodents like prairie dogs and rats. There are two other forms: septicemic plague that spreads through the whole body, and pneumonic plague that infects the lungs. Pneumonic plague is the most deadly and easiest to spread.

Stanford researchers have developed a blood-based AI tool that calculates the biological age of individual organs to reveal early signs of aging-related disease. The Mercury News reports: The tool, unveiled in Nature Medicine Wednesday, was developed by a research team spearheaded by Tony Wyss-Coray. Wyss-Coray, a Stanford Medicine professor who has spent almost 15 years fixated on the study of aging, said that the tool could "change our approach to health care." Scouring a single draw of blood for thousands of proteins, the tool works by first comparing the levels of these proteins with their average levels at a given age. An artificial intelligence algorithm then uses these gaps to derive a "biological age" for each organ.

To test the accuracy of these "biological ages," the researchers processed data for 45,000 people from the UK Biobank, a database that has kept detailed health information from over half a million British citizens for the last 17 years. When they analyzed the data, the researchers found a clear trend for all 11 organs they studied; biologically older organs were significantly more likely to develop aging-related diseases than younger ones. For instance, those with older hearts were at much higher risk for atrial fibrillation or heart failure, while those with older lungs were much more likely to develop chronic obstructive pulmonary disease.

But the brain's biological age, Wyss-Coray said, was "particularly important in determining or predicting how long you're going to live." "If you have a very young brain, those people live the longest," he said. "If you have a very old brain, those people are going to die the soonest out of all the organs we looked at." Indeed, for a given chronological age, those with "extremely aged brains" -- the 7% whose brains scored the highest on biological age -- were over 12 times more likely to develop Alzheimer's disease over the next decade than those with "extremely youthful brains" -- the 7% whose brains inhabited the other end of the spectrum.

Wyss-Coray's team also found several factors -- smoking, alcohol, poverty, insomnia and processed meat consumption -- were directly correlated with biologically aged organs. Poultry consumption, vigorous exercise, and oily fish consumption were among the factors correlated with biologically youthful organs. Supplements like glucosamine and estrogen replacements also seemed to have "protective effects," Wyss-Coray said. [...] The test ... would cost $200 once it could be operated at scale.

A new study found that psilocybin treatment significantly delayed cellular aging, extending human cell lifespan by over 50% and increasing survival in aged mice by 30%. The compound appeared to achieve these effects by reducing oxidative stress, preserving telomeres, and improving DNA repair. Neuroscience News reports: A newly published study in Nature Partner Journals' Aging demonstrates that psilocin, a byproduct of consuming psilocybin, the active ingredient in psychedelic mushrooms, extended the cellular lifespan of human skin and lung cells by more than 50%. In parallel, researchers also conducted the first long-term in vivo study evaluating the systemic effects of psilocybin in aged mice of 19 months, or the equivalent of 60-65 human years. Results indicated that the mice that received an initial low dose of psilocybin of 5 mg, followed by a monthly high dose of 15 mg for 10 months, had a 30% increase in survival compared to mice that did not receive any. These mice also displayed healthier physical features, such as improved fur quality, fewer white hairs and hair regrowth.

While traditionally researched for its mental health benefits, this study suggests that psilocybin impacts multiple hallmarks of aging by reducing oxidative stress, improving DNA repair responses, and preserving telomere length. Telomeres are the structured ends of a chromosome, protecting it from damage that could lead to the formation of age-related diseases, such as cancer, neurodegeneration, or cardiovascular disease. These foundational processes influence human aging and the onset of these chronic diseases. The study concludes that psilocybin may have the potential to revolutionize anti-aging therapies and could be an impactful intervention in an aging population.

An anonymous reader quotes a report from The Guardian: Automated surgery could be trialled on humans within a decade, say researchers, after an AI-trained robot armed with tools to cut, clip and grab soft tissue successfully removed pig gall bladders without human help. The robot surgeons were schooled on video footage of human medics conducting operations using organs taken from dead pigs. In an apparent research breakthrough, eight operations were conducted on pig organs with a 100% success rate by a team led by experts at Johns Hopkins University in Baltimore in the US. [...]

The technology allowing robots to handle complex soft tissues such as gallbladders, which release bile to aid digestion, is rooted in the same type of computerized neural networks that underpin widely used artificial intelligence tools such as Chat GPT or Google Gemini. The surgical robots were slightly slower than human doctors but they were less jerky and plotted shorter trajectories between tasks. The robots were also able to repeatedly correct mistakes as they went along, asked for different tools and adapted to anatomical variation, according to a peer-reviewed paper published in the journal Science Robotics. The authors from Johns Hopkins, Stanford and Columbia universities called it "a milestone toward clinical deployment of autonomous surgical systems." [...]

In the Johns Hopkins trial, the robots took just over five minutes to carry out the operation, which required 17 steps including cutting the gallbladder away from its connection to the liver, applying six clips in a specific order and removing the organ. The robots on average corrected course without any human help six times in each operation. "We were able to perform a surgical procedure with a really high level of autonomy," said Axel Krieger, assistant professor of mechanical engineering at Johns Hopkins. "In prior work, we were able to do some surgical tasks like suturing. What we've done here is really a full procedure. We have done this on eight gallbladders, where the robot was able to perform precisely the clipping and cutting step of gallbladder removal without any human intervention. "So I think it's a really big landmark study that such a difficult soft tissue surgery is possible to do autonomously." Currently, nearly all of the NHS's 70,000 annual robotic surgeries are human-controlled, but the UK plans to expand robot-assisted procedures to 90% within the next decade.

Google DeepMind's chief business officer says Alphabet's drug-discovery company Isomorphic Labs "is preparing to launch human trials of AI-designed drugs," according to a report in Fortune, "pairing cutting-edge AI with pharma veterans to design medicines faster, cheaper, and more accurately." "There are people sitting in our office in King's Cross, London, working, and collaborating with AI to design drugs for cancer," said Colin Murdoch [DeepMind's chief business officer and president of Isomorphic Labs]. "That's happening right now."

After years in development, Murdoch says human clinical trials for Isomorphic's AI-assisted drugs are finally in sight. "The next big milestone is actually going out to clinical trials, starting to put these things into human beings," he said. "We're staffing up now. We're getting very close."

The company, which was spun out of DeepMind in 2021, was born from one of DeepMind's most celebrated breakthroughs, AlphaFold, an AI system capable of predicting protein structures with a high level of accuracy. Interactions of AlphaFold progressed from being able to accurately predict individual protein structures to modeling how proteins interact with other molecules like DNA and drugs. These leaps made it far more useful for drug discovery, helping researchers design medicines faster and more precisely, turning the tool into a launchpad for a much larger ambition... In 2024, the same year it released AlphaFold 3, Isomorphic signed major research collaborations with pharma companies Novartis and Eli Lilly. A year later, in April 2025, Isomorphic Labs raised $600 million in its first-ever external funding round, led by Thrive Capital. The deals are part of Isomorphic's plan to build a "world-class drug design engine..."

Today, pharma companies often spend millions attempting to bring a single drug to market, sometimes with just a 10% chance of success once trials begin. Murdoch believes Isomorphic's tech could radically improve those odds. "We're trying to do all these things: speed them up, reduce the cost, but also really improve the chance that we can be successful," he says. He wants to harness AlphaFold's technology to get to a point where researchers have 100% conviction that the drugs they are developing are going to work in human trials. "One day we hope to be able to say — well, here's a disease, and then click a button and out pops the design for a drug to address that disease," Murdoch said. "All powered by these amazing AI tools."

"A computer science degree used to be a golden ticket to the promised land of jobs," a college senior tells the New York Times. But "That's no longer the case."

The article notes that in the last three years there's been a 65% drop from companies seeking workers with two years of experience or less (according to an analysis by technology research/education organization CompTIA), with tech companies "relying more on AI for some aspects of coding, eliminating some entry-level work."

So what do college professors teach when AI "is coming fastest and most forcefully to computer science"? Computer science programs at universities across the country are now scrambling to understand the implications of the technological transformation, grappling with what to keep teaching in the AI era. Ideas range from less emphasis on mastering programming languages to focusing on hybrid courses designed to inject computing into every profession, as educators ponder what the tech jobs of the future will look like in an AI economy... Some educators now believe the discipline could broaden to become more like a liberal arts degree, with a greater emphasis on critical thinking and communication skills.

The National Science Foundation is funding a program, Level Up AI, to bring together university and community college educators and researchers to move toward a shared vision of the essentials of AI education. The 18-month project, run by the Computing Research Association, a research and education nonprofit, in partnership with New Mexico State University, is organising conferences and roundtables and producing white papers to share resources and best practices. The NSF-backed initiative was created because of "a sense of urgency that we need a lot more computing students — and more people — who know about AI in the workforce," said Mary Lou Maher, a computer scientist and a director of the Computing Research Association.

The future of computer science education, Maher said, is likely to focus less on coding and more on computational thinking and AI literacy. Computational thinking involves breaking down problems into smaller tasks, developing step-by-step solutions and using data to reach evidence-based conclusions. AI literacy is an understanding — at varying depths for students at different levels — of how AI works, how to use it responsibly and how it is affecting society. Nurturing informed skepticism, she said, should be a goal.
The article raises other possibilities. Experts also suggest the possibility of "a burst of technology democratization as chatbot-style tools are used by people in fields from medicine to marketing to create their own programs, tailored for their industry, fed by industry-specific data sets." Stanford CS professor Alex Aiken even argues that "The growth in software engineering jobs may decline, but the total number of people involved in programming will increase."

Last year, Carnegie Mellon actually endorsed using AI for its introductory CS courses. The dean of the school's undergraduate programs believes that coursework "should include instruction in the traditional basics of computing and AI principles, followed by plenty of hands-on experience designing software using the new tools."

"Some of our basic assumptions about the biological process of aging might be wrong," reports the New York Times — citing new research on a small Indigenous population in the Bolivian Amazon. [Alternate URL here.] Scientists have long believed that long-term, low-grade inflammation — also known as "inflammaging" — is a universal hallmark of getting older. But this new data raises the question of whether inflammation is directly linked to aging at all, or if it's linked to a person's lifestyle or environment instead. The study, which was published Monday, found that people in two nonindustrialized areas experienced a different kind of inflammation throughout their lives than more urban people — likely tied to infections from bacteria, viruses and parasites rather than the precursors of chronic disease. Their inflammation also didn't appear to increase with age.

Scientists compared inflammation signals in existing data sets from four distinct populations in Italy, Singapore, Bolivia and Malaysia; because they didn't collect the blood samples directly, they couldn't make exact apples-to-apples comparisons. But if validated in larger studies, the findings could suggest that diet, lifestyle and environment influence inflammation more than aging itself, said Alan Cohen, an author of the paper and an associate professor of environmental health sciences at Columbia University. "Inflammaging may not be a direct product of aging, but rather a response to industrialized conditions," he said, adding that this was a warning to experts like him that they might be overestimating its pervasiveness globally.

"How we understand inflammation and aging health is based almost entirely on research in high-income countries like the U.S.," said Thomas McDade, a biological anthropologist at Northwestern University. But a broader look shows that there's much more global variation in aging than scientists previously thought, he added... McDade, who has previously studied inflammation in the Tsimane group, speculated that populations in nonindustrialized regions might be exposed to certain microbes in water, food, soil and domestic animals earlier in their lives, bolstering their immune response later in life.
More from The Independent: Chronic inflammation is thought to speed up the ageing process and contribute to various health conditions such as Alzheimer's disease, arthritis, cancer, heart disease, and Type 2 diabetes... However, other experts shared a word of caution before jumping to conclusions from the study. Vishwa Deep Dixit, director of the Yale Center for Research on Aging, told the New York Times it's not surprising that people less exposed to pollution would see lower rates of chronic disease.
Aurelia Santoro, an associate professor at the University of Bologna, also cautioned about the results, according to the Times. "While they had lower rates of chronic disease, the two Indigenous populations tended to have life spans shorter than those of people in industrialized regions, meaning they may simply not have lived long enough to develop inflammaging, Santoro said."

And Bimal Desai, a professor of pharmacology who studies inflammation at the University of Virginia School of Medicine, told the Times that the study "sparks valuable discussion" but needs more follow-up "before we rewrite the inflammaging narrative."

A new study analyzing data from more than 60 previous research projects has found evidence that there is "no safe amount" of processed meat consumption -- so much so that even small daily portions are being linked to increased disease risk.

The research, published Monday in the journal Nature Medicine, examined connections between processed meats, sugar-sweetened beverages and trans fatty acids and the risk of type 2 diabetes, colorectal cancer and ischemic heart disease. People who ate as little as one hot dog daily showed an 11% greater risk of type 2 diabetes and 7% increased risk of colorectal cancer compared to those who consumed none. Drinking approximately one 12-ounce soda per day was associated with an 8% increase in type 2 diabetes risk and 2% increased risk of ischemic heart disease.

Moderna's mRNA-based seasonal flu vaccine proved 27% more effective at preventing influenza infections than standard flu shots in a Phase 3 trial involving nearly 41,000 people aged 50 and above, the firm said this week.

The company announced that mRNA-1010 had an overall vaccine efficacy that was 26.6% higher than conventional shots, rising to 27.4% higher in participants aged 65 and older during the six-month study period. The 2024-2025 flu season hospitalized an estimated 770,000 Americans, according to the Centers for Disease Control and Prevention.

Microsoft's new AI diagnostic system achieved 80% accuracy in diagnosing patients compared to 20% for human doctors, while reducing costs by 20%, according to company research published Monday. The MAI Diagnostic Orchestrator queries multiple leading AI models including OpenAI's GPT, Google's Gemini, Anthropic's Claude, Meta's Llama, and xAI's Grok in what the company describes as a "chain-of-debate style" approach.

The system was tested against 304 case studies from the New England Journal of Medicine using Microsoft's Sequential Diagnosis Benchmark, which breaks down each case into step-by-step diagnostic processes that mirror how human physicians work. Microsoft CEO of AI Mustafa Suleyman called the development "a genuine step toward medical superintelligence."

Seven people have now received Neuralink's N1 brain implant, which enables individuals with ALS or spinal cord injuries to control a computer with their thoughts. PCMag reports: In a February 2025 update, Neuralink confirmed that three people had received its brain-computer interface (BCI). That increased to five by June, when it also reported a $650 million funding round. We're now at seven, Barrow tweeted today; Neuralink retweeted that message.

Six of the seven are participating in the PRIME study, conducted by Barrow, which handles the implantations from its Phoenix, Arizona, office. It aims to prove that the N1 implant, the R1 surgical robot, and the N1 User App on the computer are safe and effective, according to the program brochure. (No BCIs have been approved by the US Food and Drug Administration.)

Participants in the study get the implant through a surgery in which a custom-built robotic arm drills a hole in their skull and implants the device. The implant connects to a computer via Bluetooth, allowing patients to move the cursor, select words to type, browse the web, and even play video games -- a favorite activity of Neuralink's first human patient, Noland Arbaugh, who can do this all without moving any limbs or fingers. [...] Arbaugh, now 31, became paralyzed during a diving accident. Other Neuralink patients include Alex, a former machine parts builder who lost function of his arms and uses his N1 Implant to design 3D machine parts with computer-aided design (CAD). The third patient is Brad, the first person with ALS to receive the N1 implant, according to Barrow.

Mike is the fourth patient, and "the first person with a full-time job to use the N1 Implant," Barrow says. "He worked as a survey technician for city government and spent the majority of his time in the field until his ALS made the work too difficult. Like Alex, Mike has used CAD software with his Neuralink device to continue doing survey work from home and provide for his family." The fifth publicly named patient is RJ, a veteran who became paralyzed after a motorcycle accident, according to the University of Miami. The other two patients remain anonymous, but we can expect Neuralink to continue recruiting more people (here's how to apply).

An anonymous reader quotes a report from Neuroscience News Science Magazine: Surgeons have performed the first fully robotic heart transplant in the U.S., using advanced robotic tools to avoid opening the chest. [...] Using a surgical robot, lead surgeon Dr. Kenneth Liao and his team made small, precise incisions, eliminating the need to open the chest and break the breast bone. Liao removed the diseased heart, and the new heart was implanted through preperitoneal space, avoiding chest incision.

"Opening the chest and spreading the breastbone can affect wound healing and delay rehabilitation and prolong the patient's recovery, especially in heart transplant patients who take immunosuppressants," said Liao, professor and chief of cardiothoracic transplantation and circulatory support at Baylor College of Medicine and chief of cardiothoracic transplantation and mechanical circulatory support at Baylor St. Luke's Medical Center. "With the robotic approach, we preserve the integrity of the chest wall, which reduces the risk of infection and helps with early mobility, respiratory function and overall recovery."

In addition to less surgical trauma, the clinical benefits of robotic heart transplant surgery include avoiding excessive bleeding from cutting the bone and reducing the need for blood transfusions, which minimizes the risk of developing antibodies against the transplanted heart. Before the transplant surgery, the 45-year-old patient had been hospitalized with advanced heart failure since November 2024 and required multiple mechanical devices to support his heart function. He received a heart transplant in early March 2025 and after heart transplant surgery, he spent a month in the hospital before being discharged home, without complications.

An anonymous reader quotes a report from The Guardian: Swarms of tiny robots, each no larger than a speck of dust, could be deployed to cure stubborn infected sinuses before being blown out through the nose into a tissue, researchers have claimed. The micro-robots are a fraction of the width of a human hair and have been inserted successfully into animal sinuses in pre-clinical trials by researchers at universities in China and Hong Kong. Swarms are injected into the sinus cavity via a duct threaded through the nostril and guided to their target by electromagnetism, where they can be made to heat up and catalyze chemical reactions to wipe out bacterial infections. There are hopes the precisely targeted technology could eventually reduce reliance on antibiotics and other generalized medicines.

[...] The latest breakthrough, based on animal rather than human trials, involves magnetic particles "doped" with copper atoms which clinicians insert with a catheter before guiding to their target under a magnetic field. The swarms can be heated up by reacting to light from an optical fibre that is also inserted into the body as part of the therapy. This allows the micro-robots to loosen up and penetrate viscous pus that forms a barrier to the infection site. The light source also prompts the micro-robots to disrupt bacterial cell walls and release reactive oxygen species that kill the bacteria.

The study, published in Nature Robotics, showed the robots were capable of eradicating bacteria from pig sinuses and could clear infections in live rabbits with "no obvious tissue damage." The researchers have produced a model of how the technology could work on a human being, with the robot swarms being deployed in operating theatre conditions, allowing doctors to see their progress by using X-rays. Future applications could include tackling bacterial infections of the respiratory tract, stomach, intestine, bladder and urethra, they suggested. "Our proposed micro-robotic therapeutic platform offers the advantages of non-invasiveness, minimal resistance, and drug-free intervention," they said.

A groundbreaking stem cell treatment developed by Vertex Pharmaceuticals has allowed 10 out of 12 patients with severe type 1 diabetes to stop insulin therapy after one year. While the trial included some side effects and two unrelated deaths, the results mark a major step forward and have progressed to phase 3 clinical testing. ScienceAlert reports: The pancreas's islet cells are responsible for maintaining most of our bodies' insulin levels. Donor transplants of healthy versions of these cells have shown promise in treating type 1 diabetes in the past, but multiple donors are required, and donors are rare. So University of Toronto surgeon Trevor Reichman and colleagues infused 12 patients with islet cells derived from human stem cells in a treatment known as zimislecel. The patients also received immunosuppressive treatment before and after their zimislecel infusion. The islets not only produced insulin inside their bodies, but they did so at safe levels, reducing the patients' dependence on costly doses of insulin. "These findings showed that zimislecel islet cells were functional and self-regulated appropriately," the researchers write in their paper.

The mild to moderate side-effects, including decreased kidney function and the anticipated drop in immune cells, were all linked with the immunosuppressive therapy. Sadly, two additional participants died during the trial; one from an infection arising from surgery and the other from complications due to an unrelated condition. As there were no serious adverse events attributed to the new islet cell therapy, the clinical trials are have progressed into phase 3. "These findings provide evidence that pancreatic islets can be effectively produced from pluripotent stem cells and used to treat type 1 diabetes," Reichman and team conclude. The research has been published in the journal NEJM.

The number of doctoral graduates globally has grown steadily over recent decades, creating a massive imbalance between PhD holders and available academic positions. Among the 38 OECD countries, new doctorate holders almost doubled between 1998 and 2017.

China's doctoral enrollment has exploded from around 300,000 students in 2013 to more than 600,000 in 2023. This growth has forced PhD graduates into non-academic careers at unprecedented rates. A 2023 study of more than 4,500 PhD graduates in the United Kingdom found over two-thirds were employed outside academia.

In South Africa, 18% of more than 6,000 PhD graduates reported difficulty finding jobs related to their expertise. Some countries have begun adapting their doctoral programs. Japan, Germany and the United Kingdom now offer training and paid internships during doctoral studies, including "industrial PhD" programs where students conduct research in collaboration with companies.